0000000001295225

AUTHOR

H. Hakonarson

showing 2 related works from this author

Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity

2013

The pubertal height growth spurt is a distinctive feature of childhood growth reflecting both the central onset of puberty and local growth factors. Although little is known about the underlying genetics, growth variability during puberty correlates with adult risks for hormone-dependent cancer and adverse cardiometabolic health. The only gene so far associated with pubertal height growth, LIN28B, pleiotropically influences childhood growth, puberty and cancer progression, pointing to shared underlying mechanisms. To discover genetic loci influencing pubertal height and growth and to place them in context of overall growth and maturation, we performed genome-wide association meta-analyses i…

MaleNetherlands Twin Register (NTR)Genetic LinkageMedizinGene ExpressionGenome-wide association studyVARIANTSBody Mass Index0302 clinical medicinegenetic linkageTransforming Growth Factor betaNeoplasmsmolecular biologygeneticsChildGenetics (clinical)Adiposity2. Zero hunger0303 health sciencesadiposityMitogen-Activated Protein Kinase 3Association Studies ArticlesAge FactorsACHONDROPLASIAGeneral MedicineGenome-Wide Association Study; pubertal height growth; pubertal timingPhenotypeOBESITYMenarche/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingbody heightFemaleSignal Transductionmedicine.medical_specialtyage factorsCHROMOSOME 16P11.2AdolescentBIRTHQuantitative Trait Loci030209 endocrinology & metabolismContext (language use)BiologyChildhood obesitypubertal height growthMENARCHEYoung Adult03 medical and health sciencesAGESDG 3 - Good Health and Well-beingPrepubertyInternal medicineGeneticsmedicine/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_HumansMolecular Biology030304 developmental biologySignMenarcheFACTOR RECEPTOR-3MUTATIONSpubertal timingPubertyta3121medicine.diseaseObesityBody HeightGenetic architectureEndocrinologyPOPULATION COHORTgene expressionBody mass indexFollow-Up StudiesGenome-Wide Association Study
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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

2013

Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer's disease cases and 37,154 controls. In stage 2, 11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer's disease cases and 11,312 controls. In addition to the APOE locu…

MaleApolipoprotein Eepidemiology [Alzheimer Disease]SORL1Medizingenetics [Alzheimer Disease]Genome-wide association studySingle-nucleotide polymorphismBiologyPolymorphism Single NucleotideArticlePICALMCohort StudiesAlzheimer Diseaseddc:570PSEN2GeneticsmedicineHumansGenetic Predisposition to DiseaseAge of OnsetBiologyAgedGenetic associationAged 80 and overGeneticsMiddle Agedmedicine.diseaseGenetic LociCase-Control StudiesFemaleHuman medicineAlzheimer's diseasestatistics & numerical data [Genome-Wide Association Study]Genome-Wide Association StudyNature Genetics
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