0000000001295244

AUTHOR

N. Jones

showing 2 related works from this author

Electron-cooled accumulation of 4 × 109positrons for production and storage of antihydrogen atoms

2016

Four billion positrons (e+) are accumulated in a Penning–Ioffe trap apparatus at 1.2 K and <6 × 10−17 Torr. This is the largest number of positrons ever held in a Penning trap. The e+ are cooled by collisions with trapped electrons (e−) in this first demonstration of using e− for efficient loading of e+ into a Penning trap. The combined low temperature and vacuum pressure provide an environment suitable for antihydrogen () production, and long antimatter storage times, sufficient for high-precision tests of antimatter gravity and of CPT.

Condensed Matter::Quantum GasesPhysicsPhysics::General PhysicsAntiparticleAnnihilationPlasmaElectronCondensed Matter PhysicsPenning trap01 natural sciencesAtomic and Molecular Physics and Optics010305 fluids & plasmasNuclear physicsTorrAntimatter0103 physical sciencesPhysics::Atomic and Molecular ClustersPhysics::Atomic PhysicsAtomic physics010306 general physicsAntihydrogenJournal of Physics B: Atomic, Molecular and Optical Physics
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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

2013

Eleven susceptibility loci for late-onset Alzheimer&apos;s disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer&apos;s disease cases and 37,154 controls. In stage 2, 11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer&apos;s disease cases and 11,312 controls. In addition to the APOE locu…

MaleApolipoprotein Eepidemiology [Alzheimer Disease]SORL1Medizingenetics [Alzheimer Disease]Genome-wide association studySingle-nucleotide polymorphismBiologyPolymorphism Single NucleotideArticlePICALMCohort StudiesAlzheimer Diseaseddc:570PSEN2GeneticsmedicineHumansGenetic Predisposition to DiseaseAge of OnsetBiologyAgedGenetic associationAged 80 and overGeneticsMiddle Agedmedicine.diseaseGenetic LociCase-Control StudiesFemaleHuman medicineAlzheimer's diseasestatistics & numerical data [Genome-Wide Association Study]Genome-Wide Association StudyNature Genetics
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