0000000001295620

AUTHOR

H. Hampel

showing 2 related works from this author

Association between Cognitive Performance and Cortical Glucose Metabolism in Patients with Mild Alzheimer’s Disease

2004

<i>Background:</i> Neuronal and synaptic function in Alzheimer’s disease (AD) is measured in vivo by glucose metabolism using positron emission tomography (PET). <i>Objective:</i> We hypothesized that neuronal activation as measured by PET is a more sensitive index of neuronal dysfunction than activity during rest. We investigated if the correlations between dementia severity as measured with the Mini Mental State Examination (MMSE) and glucose metabolism are an artifact of brain atrophy. <i>Method:</i> Glucose metabolism was measured using [<sup>18</sup>F]fluorodeoxyglucose PET during rest and activation due to audiovisual stimulation in 13 m…

Malemedicine.medical_specialtyCognitive NeuroscienceCentral nervous system diseaseCognitionDegenerative diseaseAtrophyAlzheimer DiseaseFluorodeoxyglucose F18Internal medicinemedicineHumansDementiaBrain atrophy;Partial volume effects;Alzheimer’s disease;Metabolism;Brain imaging techniquesAgedCerebral CortexMini–Mental State Examinationmedicine.diagnostic_testBrainMiddle Agedmedicine.diseaseddc:Psychiatry and Mental healthGlucoseEndocrinologyPositron emission tomographyPositron-Emission TomographyPosterior cingulateFemaleAtrophyGeriatrics and GerontologyAlzheimer's diseaseMental Status SchedulePsychologyDementia and Geriatric Cognitive Disorders
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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

2013

Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer's disease cases and 37,154 controls. In stage 2, 11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer's disease cases and 11,312 controls. In addition to the APOE locu…

MaleApolipoprotein Eepidemiology [Alzheimer Disease]SORL1Medizingenetics [Alzheimer Disease]Genome-wide association studySingle-nucleotide polymorphismBiologyPolymorphism Single NucleotideArticlePICALMCohort StudiesAlzheimer Diseaseddc:570PSEN2GeneticsmedicineHumansGenetic Predisposition to DiseaseAge of OnsetBiologyAgedGenetic associationAged 80 and overGeneticsMiddle Agedmedicine.diseaseGenetic LociCase-Control StudiesFemaleHuman medicineAlzheimer's diseasestatistics & numerical data [Genome-Wide Association Study]Genome-Wide Association StudyNature Genetics
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