0000000001295847
AUTHOR
Bärbel Finkenstädt
Additional file 2 of 3 ′-5 ′ crosstalk contributes to transcriptional bursting
Additional file 2 Review history.
3 ′-5 ′ crosstalk contributes to transcriptional bursting
Abstract Background Transcription in mammalian cells is a complex stochastic process involving shuttling of polymerase between genes and phase-separated liquid condensates. It occurs in bursts, which results in vastly different numbers of an mRNA species in isogenic cell populations. Several factors contributing to transcriptional bursting have been identified, usually classified as intrinsic, in other words local to single genes, or extrinsic, relating to the macroscopic state of the cell. However, some possible contributors have not been explored yet. Here, we focus on processes at the 3 ′ and 5 ′ ends of a gene that enable reinitiation of transcription upon termination. Results Using Bay…
Additional file 1 of 3 ′-5 ′ crosstalk contributes to transcriptional bursting
Additional file 1 “Supporting Information to: “3’-5’ crosstalk contributes to transcriptional bursting”.