0000000001298782
AUTHOR
Alberto Lopera
Aryl-bis-(scorpiand)-aza receptors differentiate between nucleotide monophosphates by a combination of aromatic, hydrogen bond and electrostatic interactions.
Bis-polyaza pyridinophane scorpiands bind nucleotides in aqueous medium with 10–100 micromolar affinity, predominantly by electrostatic interactions between nucleotide phosphates and protonated aliphatic amines and assisted by aromatic stacking interactions. The pyridine-scorpiand receptor showed rare selectivity toward CMP with respect to other nucleotides, whereby two orders of magnitude affinity difference between CMP and UMP was the most appealing. The phenanthroline-scorpiand receptor revealed at pH 5 strong selectivity toward AMP with respect to other NMPs, based on the protonation of adenine heterocyclic N1. The results stress that the efficient recognition of small biomolecules with…
Recognition, Transformation, Detection of Nucleotides and Aqueous Nucleotide-Based Materials
Influence of the chain length and metal : ligand ratio on the self-organization processes of Cu2+ complexes of [1 + 1] 1H-pyrazole azamacrocycles
Three new [1 + 1] macrocycles formed by the reaction of 1H-3,5-bis(chloromethyl)pyrazole with the tosylated amines 1,4,7,10-tetraazadecane (L1), 1,4,8,11-tetraazaundecane (L2) and 1,5,10,14-tetraazatetradecane (L3) are described. Potentiometric studies and HR-ESI-Mass spectrometry show the formation of dimeric binuclear Cu2+ complexes whose organization depends on the type of hydrocarbon chains connecting the amine groups. Furthermore, trinuclear or/and tetranuclear complexes are formed depending also on the length of the polyaminic bridge and on the sequence of the hydrocarbon chains. The crystal structures of the [2 + 2] [Cu2(H(H−1L2))2](ClO4)4·4H2O (1) and [Cu2(H−1L2)2](ClO4)2 (2) comple…
Water and oxoanion encapsulation chemistry in a 1H-pyrazole azacryptand
Anion complexes of the cryptand built with the tripodal amine tris(2-aminoethyl)amine, known as tren, with water and several oxoanions of biological and environmental interest (nitrate, sulfate, phosphate, perchlorate and arsenate) have been crystallized from aqueous solution and resolved with single-crystal X-ray diffraction. All crystals show guest species encapsulated in the interior of the cavity as well as, in some cases, sitting in the grooves defined by the arms of the macrocycle. Hydrogen bonding and electrostatic interactions play a major role in anion binding to the host. The macrocycle is able to encapsulate anions in a wide range of protonation degrees. Solution studies have bee…
Tripyridinophane Platform Containing Three Acetate Pendant Arms: An Attractive Structural Entry for the Development of Neutral Eu(III) and Tb(III) Complexes in Aqueous Solution
We report a detailed characterization of Eu3+ and Tb3+ complexes derived from a tripyridinophane macro cycle bearing three acetate side arms (H3tpptac). Tpptac3- displays an overall basicity (Σ log KiH) of 24.5, provides the formation of mononuclear ML species, and shows a good binding affinity for Ln3+ (log KLnL = 17.5-18.7). These complexes are also thermodynamically stable at physiological pH (pEu = 18.6, pTb = 18.0). It should be noted that the pGd value of Gd-tpptac (18.4) is only slightly lower than that of commercially available MRI contrast agents such as Gd-dota (pGd = 19.2). Moreover, a very good selectivity for these ions over the endogenous cations (log KCuL = 14.4, log KZnL = 1…
Selective encapsulation of a chloride anion in a 1H-pyrazole Cu2+ metallocage
A self-assembled metallobox from copper(ii) and two macrocycles containing 1H-pyrazole ligands has been prepared. The internal cavity of the box is able to selectively encapsulate a single chloride anion over any other halide anion.
>3 + 1 = 6 + 2> In Cu(ii) coordination chemistry of 1H-pyrazole aza cryptands
A polyazamacrocycle formed from two tris(2-aminoethyl)amine units connected by 1H-pyrazole units shows unique hexanuclear Cu(ii) complexes by combination of two binuclear Cu(ii) cryptand complexes through pyrazolate moieties belonging to both cryptands. The formation of these dimeric entities has been proven both in solution by potentiometric studies and mass spectroscopy and in the solid state by X-ray diffraction of crystals of three different batches of formulae [Cu6(H-3L)2(H2O)2](TsO)6·22H2O (2), [Cu6(H-3L)2(NO3)2](NO3)4·2H2O (3) and [Cu6(H-3L)2Cl2]Cl4·(C4H5N3O2)2·14.35H2O (4). The hexanuclear unit in 2 and 4 can be viewed like three magnetically independent binuclear complexes with J =…
Hybrid GMP–polyamine hydrogels as new biocompatible materials for drug encapsulation
Here we present the preparation and characterization of new biocompatible materials for drug encapsulation. These new gels are based on positively charged [1+1] 1H-pyrazole-based azamacrocycles which minimise the electrostatic repulsions between the negatively charged GMP molecules. Rheological measurements confirm the electroneutral hydrogel structure as the most stable for all the GMP-polyamine systems. Nuclear magnetic resonance (NMR) was employed to investigate the kinetics of the hydrogel formation and cryo-scanning electron microscopy (cryo-SEM) was used to obtain information about the hydrogel morphology, which exhibited a non-homogeneous structure with a high degree of cross-linking…
CCDC 1912383: Experimental Crystal Structure Determination
Related Article: Javier Pitarch-Jarque, Kari Rissanen, Santiago García-Granda, Alberto Lopera, M. Paz Clares, Enrique García-España, Salvador Blasco|2019|New J.Chem.|43|18915|doi:10.1039/C9NJ05231C
CCDC 1964484: Experimental Crystal Structure Determination
Related Article: Nadine Leygue, Chantal Galaup, Alberto Lopera, Estefanía Delgado-Pinar, René M. Williams, Heinz Gornitzka, Jurriaan M. Zwier, Enrique García-España, Laurent Lamarque, Claude Picard|2020|Inorg.Chem.|59|1496|doi:10.1021/acs.inorgchem.9b03345
CCDC 1953932: Experimental Crystal Structure Determination
Related Article: Alberto Lopera, Ariadna Gil-Martínez, Javier Pitarch-Jarque, Begoña Verdejo, Salvador Blasco, M. Paz Clares, Hermas R. Jiménez, Enrique García-España|2020|Dalton Trans.|49|8614|doi:10.1039/D0DT01056A
CCDC 1953930: Experimental Crystal Structure Determination
Related Article: Alberto Lopera, Ariadna Gil-Martínez, Javier Pitarch-Jarque, Begoña Verdejo, Salvador Blasco, M. Paz Clares, Hermas R. Jiménez, Enrique García-España|2020|Dalton Trans.|49|8614|doi:10.1039/D0DT01056A
CCDC 1990725: Experimental Crystal Structure Determination
Related Article: Alberto Lopera, Ariadna Gil-Martínez, Javier Pitarch-Jarque, Begoña Verdejo, Salvador Blasco, M. Paz Clares, Hermas R. Jiménez, Enrique García-España|2020|Dalton Trans.|49|8614|doi:10.1039/D0DT01056A
CCDC 983272: Experimental Crystal Structure Determination
Related Article: Javier Pitarch-Jarque, Raquel Belda, Francesc Lloret, Jesús Ferrando-Soria, Pilar Navarro, Alberto Lopera, Enrique García-España|2015|Dalton Trans.|44|3378|doi:10.1039/C4DT03650F
CCDC 983271: Experimental Crystal Structure Determination
Related Article: Javier Pitarch-Jarque, Raquel Belda, Francesc Lloret, Jesús Ferrando-Soria, Pilar Navarro, Alberto Lopera, Enrique García-España|2015|Dalton Trans.|44|3378|doi:10.1039/C4DT03650F
CCDC 983274: Experimental Crystal Structure Determination
Related Article: Javier Pitarch-Jarque, Raquel Belda, Francesc Lloret, Jesús Ferrando-Soria, Pilar Navarro, Alberto Lopera, Enrique García-España|2015|Dalton Trans.|44|3378|doi:10.1039/C4DT03650F
CCDC 1994847: Experimental Crystal Structure Determination
Related Article: Javier Pitarch-Jarque, Hermas R. Jiménez, Elina Kalenius, Salvador Blasco, Alberto Lopera, M. Paz Clares, Kari Rissanen, Enrique García-España|2021|Dalton Trans.|50|9010|doi:10.1039/D1DT01302E
CCDC 1912382: Experimental Crystal Structure Determination
Related Article: Javier Pitarch-Jarque, Kari Rissanen, Santiago García-Granda, Alberto Lopera, M. Paz Clares, Enrique García-España, Salvador Blasco|2019|New J.Chem.|43|18915|doi:10.1039/C9NJ05231C
CCDC 1953929: Experimental Crystal Structure Determination
Related Article: Alberto Lopera, Ariadna Gil-Martínez, Javier Pitarch-Jarque, Begoña Verdejo, Salvador Blasco, M. Paz Clares, Hermas R. Jiménez, Enrique García-España|2020|Dalton Trans.|49|8614|doi:10.1039/D0DT01056A
CCDC 983273: Experimental Crystal Structure Determination
Related Article: Javier Pitarch-Jarque, Raquel Belda, Francesc Lloret, Jesús Ferrando-Soria, Pilar Navarro, Alberto Lopera, Enrique García-España|2015|Dalton Trans.|44|3378|doi:10.1039/C4DT03650F
CCDC 1912384: Experimental Crystal Structure Determination
Related Article: Javier Pitarch-Jarque, Kari Rissanen, Santiago García-Granda, Alberto Lopera, M. Paz Clares, Enrique García-España, Salvador Blasco|2019|New J.Chem.|43|18915|doi:10.1039/C9NJ05231C
CCDC 1994844: Experimental Crystal Structure Determination
Related Article: Javier Pitarch-Jarque, Hermas R. Jiménez, Elina Kalenius, Salvador Blasco, Alberto Lopera, M. Paz Clares, Kari Rissanen, Enrique García-España|2021|Dalton Trans.|50|9010|doi:10.1039/D1DT01302E
CCDC 1994845: Experimental Crystal Structure Determination
Related Article: Javier Pitarch-Jarque, Hermas R. Jiménez, Elina Kalenius, Salvador Blasco, Alberto Lopera, M. Paz Clares, Kari Rissanen, Enrique García-España|2021|Dalton Trans.|50|9010|doi:10.1039/D1DT01302E
CCDC 1994846: Experimental Crystal Structure Determination
Related Article: Javier Pitarch-Jarque, Hermas R. Jiménez, Elina Kalenius, Salvador Blasco, Alberto Lopera, M. Paz Clares, Kari Rissanen, Enrique García-España|2021|Dalton Trans.|50|9010|doi:10.1039/D1DT01302E
CCDC 1953933: Experimental Crystal Structure Determination
Related Article: Alberto Lopera, Ariadna Gil-Martínez, Javier Pitarch-Jarque, Begoña Verdejo, Salvador Blasco, M. Paz Clares, Hermas R. Jiménez, Enrique García-España|2020|Dalton Trans.|49|8614|doi:10.1039/D0DT01056A
CCDC 1912380: Experimental Crystal Structure Determination
Related Article: Javier Pitarch-Jarque, Kari Rissanen, Santiago García-Granda, Alberto Lopera, M. Paz Clares, Enrique García-España, Salvador Blasco|2019|New J.Chem.|43|18915|doi:10.1039/C9NJ05231C
CCDC 1912379: Experimental Crystal Structure Determination
Related Article: Javier Pitarch-Jarque, Kari Rissanen, Santiago García-Granda, Alberto Lopera, M. Paz Clares, Enrique García-España, Salvador Blasco|2019|New J.Chem.|43|18915|doi:10.1039/C9NJ05231C
CCDC 1912378: Experimental Crystal Structure Determination
Related Article: Javier Pitarch-Jarque, Kari Rissanen, Santiago García-Granda, Alberto Lopera, M. Paz Clares, Enrique García-España, Salvador Blasco|2019|New J.Chem.|43|18915|doi:10.1039/C9NJ05231C
CCDC 1912381: Experimental Crystal Structure Determination
Related Article: Javier Pitarch-Jarque, Kari Rissanen, Santiago García-Granda, Alberto Lopera, M. Paz Clares, Enrique García-España, Salvador Blasco|2019|New J.Chem.|43|18915|doi:10.1039/C9NJ05231C