0000000001299826

AUTHOR

Audrey Trommenschlager

showing 14 related works from this author

Gold(I)-Coumarin-Caffeine-Based Complexes as New Potential Anti-Inflammatory and Anticancer Trackable Agents.

2018

Three new gold(I)-coumarin-based trackable therapeutic complexes and two non-trackable analogues have been synthesised and fully characterised. They all display anti-proliferative properties on several types of cancer cell lines, including those of colon, breast, and prostate. Two complexes displayed significant anti-inflammatory effects; one displayed pro-inflammatory behaviour; this highlights the impact of the position of the fluorophore on the caffeine scaffold. Additionally, the three coumarin derivatives could be visualised in vitro by two-photon microscopy.

Fluorophoremedicine.drug_classUltraviolet RaysAnti-Inflammatory AgentsAntineoplastic Agents010402 general chemistry01 natural sciencesBiochemistryAnti-inflammatoryFluorescencechemistry.chemical_compoundCoordination ComplexesCoumarinsCaffeineCell Line TumorDrug DiscoverymedicineHumansGeneral Pharmacology Toxicology and PharmaceuticsFluorescent DyesPharmacology010405 organic chemistryOrganic ChemistryCancerCoumarinmedicine.diseaseCombinatorial chemistryIn vitro0104 chemical sciencesHEK293 CellsMicroscopy Fluorescence MultiphotonchemistryMolecular MedicineGoldCancer cell linesCaffeineChemMedChem
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Phenoxyamidine Zn and Al Complexes: Synthesis, Characterization, and Use in the Ring-Opening Polymerization of Lactide

2019

International audience; Herein we report the synthesis of new ditopic ligands, which consist of a phenoxy group and N,N,N'trisubstituted amidines linked by a methylene spacer (L1-L4). Their coordination chemistry has been studied/investigated with Zn(II) and Al(III). Alkane elimination route between the phenol-amidine proligands (L1H-L4H) and Et2Zn led to dinuclear complexes [(L1-L4)ZnEt]2 (1a-4a) in which the Zn centers are chelated by phenoxyamidine ligands and bridged through the oxygen atom of the phenoxy groups. Salt metathesis reaction between two equivalents of the sodium amidine phenate L1Na and ZnCl2 led to a bis-chelate chiral spiro-complex (L12Zn) 1a'. Analogous alkane eliminatio…

STRUCTURAL-CHARACTERIZATIONchemistry.chemical_elementCATALYSTSZinc010402 general chemistryLIGANDS SYNTHESIS01 natural sciencesRing-opening polymerizationCoordination complexCatalysisInorganic Chemistrychemistry.chemical_compoundZINCIMINE LIGANDSGroup (periodic table)Polymer chemistry[CHIM.COOR]Chemical Sciences/Coordination chemistryPhysical and Theoretical ChemistryMethyleneCYCLIC ESTERSALUMINUM COMPLEXESchemistry.chemical_classificationEPSILON-CAPROLACTONELactide010405 organic chemistryOrganic ChemistryGROUP-4 METAL-COMPLEXES[CHIM.CATA]Chemical Sciences/CatalysisImine ligands0104 chemical scienceschemistryINITIATORSGROUP-4 METAL-COMPLEXES; ALUMINUM COMPLEXES; EPSILON-CAPROLACTONE; LIGANDS SYNTHESIS; IMINE LIGANDS; STRUCTURAL-CHARACTERIZATION; CYCLIC ESTERS; ZINC; CATALYSTS; INITIATORS
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Gold( i )–BODIPY–imidazole bimetallic complexes as new potential anti-inflammatory and anticancer trackable agents

2017

International audience; Two new gold(I)–BODIPY–imidazole based trackable therapeutic bimetallic complexes have been synthesized and fully characterized. They display strong antiproliferative properties on several types of cancers including colon, breast, and prostate and one of them presents a significant anti-inflammatory effect. Additionally, the two compounds could be visualised in vitro by confocal microscopy in the submicromolar range.

Boron Compoundsmedicine.drug_classStereochemistryAnti-Inflammatory AgentsAntineoplastic Agents[SDV.CAN]Life Sciences [q-bio]/Cancer010402 general chemistry01 natural sciences[ CHIM ] Chemical SciencesAnti-inflammatorylaw.invention[ SDV.CAN ] Life Sciences [q-bio]/CancerInorganic Chemistrychemistry.chemical_compoundConfocal microscopylawCoordination ComplexesCell Line TumorDrug DiscoverymedicineImidazoleHumans[CHIM]Chemical SciencesBimetallic stripCell ProliferationFluorescent Dyes010405 organic chemistryChemistryDrug discoveryImidazolesIn vitro0104 chemical sciences3. Good healthGoldBODIPY
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CCDC 1868748: Experimental Crystal Structure Determination

2019

Related Article: Florian Chotard, Rosita Lapenta, Anaëlle Bolley, Audrey Trommenschlager, Cédric Balan, Jérôme Bayardon, Raluca Malacea-Kabbara, Quentin Bonnin, Ewen Bodio, Hélène Cattey, Philippe Richard, Stefano Milione, Alfonso Grassi, Samuel Dagorne, Pierre Le Gendre|2019|Organometallics|38|4147|doi:10.1021/acs.organomet.9b00501

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersbis(2-({[(dimethylamino)(phenyl)methylidene]amino}methyl)phenolato)-zinc(ii)Experimental 3D Coordinates
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CCDC 1828666: Experimental Crystal Structure Determination

2018

Related Article: Audrey Trommenschlager, Florian Chotard, Benoît Bertrand, Souheila Amor, Philippe Richard, Ali Bettaïeb, Catherine Paul, Jean-Louis Connat, Pierre Le Gendre, Ewen Bodio|2018|ChemMedChem|13|2408|doi:10.1002/cmdc.201800474

(7-[(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)methyl]-13-dimethyl-37-dihydro-1H-purine-26-dione)-(triphenylphosphine)-gold(i) tetrafluoroborate diethyl ether solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1868745: Experimental Crystal Structure Determination

2019

Related Article: Florian Chotard, Rosita Lapenta, Anaëlle Bolley, Audrey Trommenschlager, Cédric Balan, Jérôme Bayardon, Raluca Malacea-Kabbara, Quentin Bonnin, Ewen Bodio, Hélène Cattey, Philippe Richard, Stefano Milione, Alfonso Grassi, Samuel Dagorne, Pierre Le Gendre|2019|Organometallics|38|4147|doi:10.1021/acs.organomet.9b00501

Space GroupCrystallography2-({[phenyl(pyrrolidin-1-yl)methylidene]amino}methyl)phenolCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1868749: Experimental Crystal Structure Determination

2019

Related Article: Florian Chotard, Rosita Lapenta, Anaëlle Bolley, Audrey Trommenschlager, Cédric Balan, Jérôme Bayardon, Raluca Malacea-Kabbara, Quentin Bonnin, Ewen Bodio, Hélène Cattey, Philippe Richard, Stefano Milione, Alfonso Grassi, Samuel Dagorne, Pierre Le Gendre|2019|Organometallics|38|4147|doi:10.1021/acs.organomet.9b00501

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(2-({[(dimethylamino)(phenyl)methylidene]amino}methyl)phenolato)-bis(methyl)-aluminium(iii)Experimental 3D Coordinates
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CCDC 1828665: Experimental Crystal Structure Determination

2018

Related Article: Audrey Trommenschlager, Florian Chotard, Benoît Bertrand, Souheila Amor, Philippe Richard, Ali Bettaïeb, Catherine Paul, Jean-Louis Connat, Pierre Le Gendre, Ewen Bodio|2018|ChemMedChem|13|2408|doi:10.1002/cmdc.201800474

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(137-trimethyl-37-dihydro-1H-purine-26-dione)-(triphenylphosphine)-gold(i) tetrafluoroborateExperimental 3D Coordinates
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CCDC 1868747: Experimental Crystal Structure Determination

2019

Related Article: Florian Chotard, Rosita Lapenta, Anaëlle Bolley, Audrey Trommenschlager, Cédric Balan, Jérôme Bayardon, Raluca Malacea-Kabbara, Quentin Bonnin, Ewen Bodio, Hélène Cattey, Philippe Richard, Stefano Milione, Alfonso Grassi, Samuel Dagorne, Pierre Le Gendre|2019|Organometallics|38|4147|doi:10.1021/acs.organomet.9b00501

Space GroupCrystallographyCrystal SystemCrystal Structurebis(mu-2-({[phenyl(pyrrolidin-1-yl)methylidene]amino}methyl)phenolato)-bis(ethyl)-di-zinc(ii)Cell ParametersExperimental 3D Coordinates
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CCDC 1937786: Experimental Crystal Structure Determination

2019

Related Article: Florian Chotard, Rosita Lapenta, Anaëlle Bolley, Audrey Trommenschlager, Cédric Balan, Jérôme Bayardon, Raluca Malacea-Kabbara, Quentin Bonnin, Ewen Bodio, Hélène Cattey, Philippe Richard, Stefano Milione, Alfonso Grassi, Samuel Dagorne, Pierre Le Gendre|2019|Organometallics|38|4147|doi:10.1021/acs.organomet.9b00501

Space GroupCrystallographybis(mu-isopropoxo)-bis(N'-[(2-oxyphenyl)methyl]-NN-dimethylbenzenecarboximidamide)-di-zincCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1538131: Experimental Crystal Structure Determination

2017

Related Article: Audrey Trommenschlager, Florian Chotard, Benoît Bertrand, Souheila Amor, Lucile Dondaine, Michel Picquet, Philippe Richard, Ali Bettaïeb, Pierre Le Gendre, Catherine Paul, Christine Goze, Ewen Bodio|2017|Dalton Trans.|46|8051|doi:10.1039/C7DT01377A

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters55-difluoro-37-bis(1H-imidazol-1-yl)-10-phenyl-5H-4lambda55lambda5-dipyrrolo[12-c:2'1'-f][132]diazaborinine dichloromethane solvateExperimental 3D Coordinates
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CCDC 1868750: Experimental Crystal Structure Determination

2019

Related Article: Florian Chotard, Rosita Lapenta, Anaëlle Bolley, Audrey Trommenschlager, Cédric Balan, Jérôme Bayardon, Raluca Malacea-Kabbara, Quentin Bonnin, Ewen Bodio, Hélène Cattey, Philippe Richard, Stefano Milione, Alfonso Grassi, Samuel Dagorne, Pierre Le Gendre|2019|Organometallics|38|4147|doi:10.1021/acs.organomet.9b00501

Space GroupCrystallographyCrystal Systemdimethyl-[2-({[phenyl(pyrrolidin-1-yl)methylidene]amino}methyl)phenolato]-aluminium(iii)Crystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1868746: Experimental Crystal Structure Determination

2019

Related Article: Florian Chotard, Rosita Lapenta, Anaëlle Bolley, Audrey Trommenschlager, Cédric Balan, Jérôme Bayardon, Raluca Malacea-Kabbara, Quentin Bonnin, Ewen Bodio, Hélène Cattey, Philippe Richard, Stefano Milione, Alfonso Grassi, Samuel Dagorne, Pierre Le Gendre|2019|Organometallics|38|4147|doi:10.1021/acs.organomet.9b00501

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersbis(mu-2-({[(dimethylamino)(phenyl)methylidene]amino}methyl)phenolato)-bis(ethyl)-di-zinc(ii)Experimental 3D Coordinates
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CCDC 1868743: Experimental Crystal Structure Determination

2019

Related Article: Florian Chotard, Rosita Lapenta, Anaëlle Bolley, Audrey Trommenschlager, Cédric Balan, Jérôme Bayardon, Raluca Malacea-Kabbara, Quentin Bonnin, Ewen Bodio, Hélène Cattey, Philippe Richard, Stefano Milione, Alfonso Grassi, Samuel Dagorne, Pierre Le Gendre|2019|Organometallics|38|4147|doi:10.1021/acs.organomet.9b00501

Space GroupCrystallographyCrystal SystemCrystal StructureN-[(2-hydroxyphenyl)methyl]-N'N'-dimethylbenzenecarboximidamidium bromideCell ParametersExperimental 3D Coordinates
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