Gold(I)-Coumarin-Caffeine-Based Complexes as New Potential Anti-Inflammatory and Anticancer Trackable Agents.

6533b7d4fe1ef96bd1262078

RESEARCH PRODUCT

Gold(I)-Coumarin-Caffeine-Based Complexes as New Potential Anti-Inflammatory and Anticancer Trackable Agents.

Jean-louis Connat Benoît Bertrand Souheila Amor Pierre Le Gendre Florian Chotard Ewen Bodio Catherine Paul Catherine Paul Ali Bettaieb Ali Bettaieb Philippe Richard Audrey Trommenschlager

subject

Fluorophore medicine.drug_class Ultraviolet Rays Anti-Inflammatory Agents Antineoplastic Agents 010402 general chemistry 01 natural sciences Biochemistry Anti-inflammatory Fluorescence chemistry.chemical_compound Coordination Complexes Coumarins Caffeine Cell Line Tumor Drug Discovery medicine Humans General Pharmacology Toxicology and Pharmaceutics Fluorescent Dyes Pharmacology 010405 organic chemistry Organic Chemistry Cancer Coumarin medicine.disease Combinatorial chemistry In vitro 0104 chemical sciences HEK293 Cells Microscopy Fluorescence Multiphoton chemistry Molecular Medicine Gold Cancer cell lines Caffeine

description

Three new gold(I)-coumarin-based trackable therapeutic complexes and two non-trackable analogues have been synthesised and fully characterised. They all display anti-proliferative properties on several types of cancer cell lines, including those of colon, breast, and prostate. Two complexes displayed significant anti-inflammatory effects; one displayed pro-inflammatory behaviour; this highlights the impact of the position of the fluorophore on the caffeine scaffold. Additionally, the three coumarin derivatives could be visualised in vitro by two-photon microscopy.

year	journal	country	edition	language
2018-07-16	ChemMedChem

10.1002/cmdc.201800474 https://pubmed.ncbi.nlm.nih.gov/30203922

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