0000000001299969
AUTHOR
Denys Mavrynsky
showing 9 related works from this author
Cytotoxicities of Polysubstituted Chlorodicarbonyl(cyclopentadienyl) and (Indenyl)ruthenium Complexes
2013
Polysubstituted cyclopentadienyl and indenyl complexes of ruthenium were synthesized and investigated to elucidate their potential cytotoxic activities. In particular, substituted (indenyl)ruthenium complexes inhibited the proliferation of a panel of human adherent cancer cells with comparable activity to reference agent cisplatin. One of the active compounds exerted a concentration dependent inhibition of cell cycle at G1–S transiton as evidenced by flow cytometry.
Improved synthesis of Bn5CpRu(CO)2Cl and its application as racemization catalyst in preparative-scale metalloenzymatic dynamic kinetic resolution of…
2010
An improved gram-scale synthesis of Bn5CpRu(CO)2Cl is reported based on heating of pentabenzylcyclopentadiene with Ru3(CO)12 at 160 °C under argon atmosphere in mesitylene followed by addition of chloroform, continued heating, and evaporation of the solvents. Subsequent washing of unreacted ligand precursor with hexane provided pure title compound in 77 % yield. In combination with Candida antarctica lipase B (CAL-B) (Novozym 435), this complex forms a highly active racemization catalyst for metallo-enzymatic dynamic kinetic resolution (DKR) of secondary alcohols as demonstrated in the present work by converting 100 g of racemic 1-phenylethanol to (R)-1-phenylethanol in >99 % ee and 93 %…
Cyclopenta[l]phenanthrenyl and Cyclopenta[a]acenaphthylenyl Half-Sandwich Complexes of Ruthenium as Racemization Catalysts for Secondary Alcohols
2008
Several half-sandwich complexes of ruthenium with cyclopenta[l]phenanthrenyl and cyclopenta[a]acenaphthylenyl ligands containing fused aromatic ring substituents on the cyclopentadienyl ring were p...
Dicarbonylchloro(pentabenzylcyclopentadienyl)ruthenium as Racemization Catalyst in the Dynamic Kinetic Resolution of Secondary Alcohols
2009
Dicarbonylchloro(pentabenzylcyclopentadienyl)ruthenium has been prepared and its structure confirmed by X-ray analysis. This complex shows excellent catalytic activity and modest stability against air in racemization reactions of secondary alcohols. In Candida antarctica lipase B (CAL-B) catalyzed dynamic kinetic resolution (DKR) of 1-phenyl- and 1-(furan-2-yl)ethanol compounds, the new complex shows improved performance as an alcohol racemization catalyst in comparison with its well-known pentaphenylcyclopentadienyl analogue, hitherto considered as the leading catalyst candidate. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
CCDC 713845: Experimental Crystal Structure Determination
2016
Related Article: Denys Mavrynsky, Mari Päiviö, Katri Lundell, Reijo Sillanpää, Liisa T. Kanerva, Reko Leino|2009|Eur.J.Org.Chem.|2009|1317|doi:10.1002/ejoc.200801248
CCDC 713844: Experimental Crystal Structure Determination
2016
Related Article: Denys Mavrynsky, Mari Päiviö, Katri Lundell, Reijo Sillanpää, Liisa T. Kanerva, Reko Leino|2009|Eur.J.Org.Chem.|2009|1317|doi:10.1002/ejoc.200801248
CCDC 929860: Experimental Crystal Structure Determination
2013
Related Article: Denys Mavrynsky, Jani Rahkila, Daniel Bandarra, Soraia Martins, Margarida Meireles, Maria José Calhorda, Ida J. Kovács, István Zupkó, Mikko M. Hänninen, and Reko Leino|2013|Organometallics|32|3012|doi:10.1021/om400234p
CCDC 929859: Experimental Crystal Structure Determination
2013
Related Article: Denys Mavrynsky, Jani Rahkila, Daniel Bandarra, Soraia Martins, Margarida Meireles, Maria José Calhorda, Ida J. Kovács, István Zupkó, Mikko M. Hänninen, and Reko Leino|2013|Organometallics|32|3012|doi:10.1021/om400234p
CCDC 798985: Experimental Crystal Structure Determination
2017
Related Article: Denys Mavrynsky, Liisa T. Kanerva, Reijo Sillanpää, and Reko Leino|2011|Pure Appl.Chem.|83|479|doi:10.1351/PAC-CON-10-09-05