0000000001303273
AUTHOR
Stefan Bräse
Cytotoxicity and NMR Studies of Platinum Complexes with Cyclooctadiene Ligands
The synthesis of a series of platinum complexes containing cyclooctadiene ligands with the general structure PtMeL(R-cod) (where L = Cl, I, nC3F7, iC3F7, nC8F17, Me, aryl, alkynyl and R = H, Me, Et, iPr, nBu, iBu, nHex, Ph) is presented. All complexes are remarkably stable and were obtained in excellent yields. Their structure in both solution and the solid state were explored by crystal structures and multinuclear (1H, 13C, 19F, 195Pt) NMR spectroscopy. Cytotoxicity experiments with selected complexes in HeLa cells revealed higher toxicity in comparison to that of cisplatin for most of the structures.
Single and Multiple Additions of Dibenzoylmethane onto Buckminsterfullerene
A novel dibenzoylmethane-fullerene e,e,e-tris adduct was synthesized by the application of a variation of the Bingel–Hirsch conditions and characterized among others by X-ray crystallography. In addition, the corresponding hexakis adduct was detected by MALDI-TOF-MS analysis. Its existence was supported by density-functional-theory (DFT) computations. Furthermore a new synthesis of bis(benzoyl)methanofullerene was established, and its molecular structure was elucidated by X-ray crystallography. DFT computations reproduced the experimentally determined conformation and predict a low energy barrier for the rotation of the two benzoyl moieties.
Structurally diverse second-generation [2.2]paracyclophane ketimines with planar and central chirality: syntheses, structural determination, and evaluation for asymmetric catalysis.
A set of 20 novel [2.2]paracyclophane ketimines with planar and central chirality has been synthesized from enantiomerically pure and racemic 5-acyl-4-hydroxy[2.2]paracyclophane and alpha-branched chiral amines. Their X-ray structures were determined to elucidate the three-dimensional structures and the absolute configuration. The ketimines were used as catalysts in the asymmetric 1,2-addition reactions of diethylzinc with substituted benzaldehydes to furnish chiral alcohols in up to 95 % ee.
Synthesis and Topological Determination of Hexakis-Substituted 1,4-Ditritylbenzene and Nonakis-Substituted 1,3,5-Tritritylbenzene Derivatives: Building Blocks for Higher Supramolecular Assemblies
Based on trityl moieties, novel organic building blocks have been prepared and structurally investigated. Substituted hexaphenyl-p-xylene (1,4-ditritylbenzene) as well as extended analogues thereof were prepared. Furthermore, a new family based on a 1,3,5-tritritylbenzene motif, connecting three trityl groups through a formal mesitylene unit, was developed. Both families were further converted through six- and nine-fold substitution reactions, respectively, to yield potent molecular building blocks for supramolecular assemblies.
Single and Multiple Additions of Dibenzoylmethane onto Buckminsterfullerene (Eur. J. Org. Chem. 35/2013)
Synthesis of Azido-Glycans for Chemical Glycomodification of Proteins
CCDC 993792: Experimental Crystal Structure Determination
Related Article: Mirja Enders, Benjamin Görling, Alexander B. Braun, Judith E. Seltenreich, Linus F. Reichenbach, Kari Rissanen, Martin Nieger, Burkhard Luy, Ute Schepers, and Stefan Bräse|2014|Organometallics|33|4027|doi:10.1021/om500540x
CCDC 949721: Experimental Crystal Structure Determination
Related Article: Alexander Giovannitti, Stefan M. Seifermann, Angela Bihlmeier, Thierry Muller, Filip Topic, Kari Rissanen, Martin Nieger, Wim Klopper, and Stefan Bräse|2013|Eur.J.Org.Chem.|2013|7907|doi:10.1002/ejoc.201301146
CCDC 949723: Experimental Crystal Structure Determination
Related Article: Alexander Giovannitti, Stefan M. Seifermann, Angela Bihlmeier, Thierry Muller, Filip Topic, Kari Rissanen, Martin Nieger, Wim Klopper, and Stefan Bräse|2013|Eur.J.Org.Chem.|2013|7907|doi:10.1002/ejoc.201301146
CCDC 993789: Experimental Crystal Structure Determination
Related Article: Mirja Enders, Benjamin Görling, Alexander B. Braun, Judith E. Seltenreich, Linus F. Reichenbach, Kari Rissanen, Martin Nieger, Burkhard Luy, Ute Schepers, and Stefan Bräse|2014|Organometallics|33|4027|doi:10.1021/om500540x
CCDC 1565153: Experimental Crystal Structure Determination
Related Article: Mirella Wawryszyn, Paul F. Sauter, Martin Nieger, Martin R.Koos, Christine Koehler, Burkhard Luy, Edward A. Lemke, Stefan Bräse|2018|Eur.J.Org.Chem.|2018|4296|doi:10.1002/ejoc.201800602
CCDC 1565150: Experimental Crystal Structure Determination
Related Article: Mirella Wawryszyn, Paul F. Sauter, Martin Nieger, Martin R.Koos, Christine Koehler, Burkhard Luy, Edward A. Lemke, Stefan Bräse|2018|Eur.J.Org.Chem.|2018|4296|doi:10.1002/ejoc.201800602
CCDC 1565151: Experimental Crystal Structure Determination
Related Article: Mirella Wawryszyn, Paul F. Sauter, Martin Nieger, Martin R.Koos, Christine Koehler, Burkhard Luy, Edward A. Lemke, Stefan Bräse|2018|Eur.J.Org.Chem.|2018|4296|doi:10.1002/ejoc.201800602
CCDC 993790: Experimental Crystal Structure Determination
Related Article: Mirja Enders, Benjamin Görling, Alexander B. Braun, Judith E. Seltenreich, Linus F. Reichenbach, Kari Rissanen, Martin Nieger, Burkhard Luy, Ute Schepers, and Stefan Bräse|2014|Organometallics|33|4027|doi:10.1021/om500540x
CCDC 949722: Experimental Crystal Structure Determination
Related Article: Alexander Giovannitti, Stefan M. Seifermann, Angela Bihlmeier, Thierry Muller, Filip Topic, Kari Rissanen, Martin Nieger, Wim Klopper, and Stefan Bräse|2013|Eur.J.Org.Chem.|2013|7907|doi:10.1002/ejoc.201301146
CCDC 1565154: Experimental Crystal Structure Determination
Related Article: Mirella Wawryszyn, Paul F. Sauter, Martin Nieger, Martin R.Koos, Christine Koehler, Burkhard Luy, Edward A. Lemke, Stefan Bräse|2018|Eur.J.Org.Chem.|2018|4296|doi:10.1002/ejoc.201800602
CCDC 949720: Experimental Crystal Structure Determination
Related Article: Alexander Giovannitti, Stefan M. Seifermann, Angela Bihlmeier, Thierry Muller, Filip Topic, Kari Rissanen, Martin Nieger, Wim Klopper, and Stefan Bräse|2013|Eur.J.Org.Chem.|2013|7907|doi:10.1002/ejoc.201301146
CCDC 993788: Experimental Crystal Structure Determination
Related Article: Mirja Enders, Benjamin Görling, Alexander B. Braun, Judith E. Seltenreich, Linus F. Reichenbach, Kari Rissanen, Martin Nieger, Burkhard Luy, Ute Schepers, and Stefan Bräse|2014|Organometallics|33|4027|doi:10.1021/om500540x
CCDC 993791: Experimental Crystal Structure Determination
Related Article: Mirja Enders, Benjamin Görling, Alexander B. Braun, Judith E. Seltenreich, Linus F. Reichenbach, Kari Rissanen, Martin Nieger, Burkhard Luy, Ute Schepers, and Stefan Bräse|2014|Organometallics|33|4027|doi:10.1021/om500540x
CCDC 1565152: Experimental Crystal Structure Determination
Related Article: Mirella Wawryszyn, Paul F. Sauter, Martin Nieger, Martin R.Koos, Christine Koehler, Burkhard Luy, Edward A. Lemke, Stefan Bräse|2018|Eur.J.Org.Chem.|2018|4296|doi:10.1002/ejoc.201800602
CCDC 949724: Experimental Crystal Structure Determination
Related Article: Alexander Giovannitti, Stefan M. Seifermann, Angela Bihlmeier, Thierry Muller, Filip Topic, Kari Rissanen, Martin Nieger, Wim Klopper, and Stefan Bräse|2013|Eur.J.Org.Chem.|2013|7907|doi:10.1002/ejoc.201301146