Extractive-spectrophotometric determination of amphetamine in urine samples with sodium 1,2-naphthoquinone 4-sulphonate

Abstract Sodium 1,2-naphthoquinone 4-sulphonate (NQS) was tested as a reagent for amphetamine in order to develop an extractive-spectrophotometric method for the drug in urine samples. The standard additions method showed the absence of proportional bias error whereas the Youden method and the two standard addition plots method showed the presence of a constant bias error [total Youden blank (TYB)]. Acceptable results were obtained by evaluating the TYB error or by using a placebo (urine sample from a normal subject). The dynamic range of concentrations was 1.4–50 mg 1−1 in urine samples and the detection limit was 0.6 mg 1−1 when 10 ml of urine sample were taken.

Determinación de anfetamina, metanfetamina y efedrina con el reactivo espectrofotométrico 1,2-naftoquinona 4-sulfonato en muestras de orina y fármacos : tratamiento preventivo y estudio analítico-quimiométrico de los procedimientos extractivo, con o sin separación cromatográfica, y cinético en disolución acuosa

Kinetic-Spectrophotometric Determination of Primary and Secondary Amines by Reaction with 1-2 Naphthoquinone-4-Sulphonate.

Abstract A kinetic-spectrophotometric method for the determination of primary and secondary amines is described. It is based on the coloured reaction of these amines with sodium 1,2 Naphthoquinone 4-sulphonate (NQS) in the presence of a non-ionic surfactant. For each determination the optimum conditions were studied and found to be as follows: pH 10.5. Carbonate-bicarbonate buffer 0.1M, Triton X-100 0.1%, Temperature 45°C, and NQS 6.4 × 10−3 M and interval of time 45–180s at wavelength 490 nm. The parameters used for the quantitative determinations are the reaction rate and the increase in the absorbance of the kinetic curves. This procedure has been applied to the determination of ephedrin…

Interpretation and Chemometric Evaluation of the Bilirubin Interference in the Kinetic Spectrophotometry Determination of Creatinine in Serum by Use of the Jaffe Reaction

Abstract SUMMARY In an alkaline picrate medium we demonstrated the occurrence of isosbestic points over the range 520–550 nm, the position depending on the bilirubin content and less on the albumin content. Bilirubin does not markedly modify the ratt constant of the reaction between creatinine and picrate, however, it does modify the intercept of the Ln ΔA vs t, plots. The absolute value of Ln ΔA varies with the concentration, though not with time, which indicates that bilirubin acts by consuming part of the initially present creatinine irrespective of its owr concentration at the wavelengths typically used in the creatinine determination. The Ln ΔA values at the isosbestic points coincide …

Derivatization of amphetamine and methamphetamine with 1,2-naphthoquinone 4-sulfonic acid into solid-phase extraction cartridges. Determination of amphetamine in pharmaceutical and urine samples.

The derivatization of amphetamine and methamphetamine with 1,2-naphthoquinone-4-sulfonate (NQS) into solid-phase extraction cartridges (C 18 ) is described. Optimum conditions were the use of carbonate–hydrogencarbonate buffer of pH 10, a 10 min reaction time at 25 °C and an NQS concentration of 9.6 × 10 - 3 M. The accuracy and the precision of the method were tested. The results obtained with the proposed liquid–solid procedure were compared with those obtained with a traditional liquid–liquid extraction with hexane–ethyl acetate. The procedure was used to measure amphetamine in pharmaceutical and urine samples

La investigación en los delitos relativos al tráfico y consumo de drogas

Mesa redonda en el marco de la jornada ''La ciencia al servicio de la criminología''. Facultad de Derecho. Universitat de ValènciaDuración: 29M

Prevenció de riscs laborals en el laboratori de química analítica (PRLQA)

Es tracta de la web que recopila les activitats dels membres del gid relacionades amb temes docents pel que s’inclouen vídeos, qüestionaris, comunicacions a congressos i publicacions. Se trata de la web que recopila las actividades de los miembros del grupo de innovación docente relacionadas con temas docentes por lo que se incluyen videos, cuestionarios, comunicaciones a congresos y publicaciones. The web reports the results of gid members related to educational activity. The web includes videos, questionnaires, congress communications and publications.

Desarrollo de material multimedia para la prevención de riesgos en el laboratorio docente de Química Analítica. Segunda parte: Laboratorio de Instrumentación.

El material consta de un video y un cuestionario. El video contiene información básica sobre la prevención y riesgos que conlleva la utilización y manejo de instrumentación en los laboratorios de Química Analítica. Se abordan los aspectos generales sobre el trabajo seguro en un laboratorio de instrumentación analítica, así como los riesgos específicos de las principales técnicas analíticas: espectroscopia molecular, espectroscopia atómica, métodos eléctricos y métodos cromatográficos. Finalmente, el cuestionario contiene diversas preguntas relacionadas con las conductas de trabajo adecuadas para la prevención de riesgos en el laboratorio de instrumentación analítica. El material consta d'un…