0000000001305718

AUTHOR

Markus Kipp

showing 5 related works from this author

Water-Soluble Cuprizone Derivative: Synthesis, Characterization, and in Vitro Studies

2019

The cuprizone mouse model is one of the most accepted model systems for the investigation of oligodendrocyte degeneration, a process critically involved in the pathogenesis of diseases such as multiple sclerosis or schizophrenia. In order to substitute the in vivo experiments by in vitro approaches, the amine derivative BiMPi is introduced as a water-soluble alternative to cuprizone. Regarding superoxide dismutase activity, toxicity for oligodendrocytes, and disturbance of mitochondrial membrane potential, BiMPi shows similar in vitro effects as is observed in vivo for cuprizone. peerReviewed

synthesispatogeneesiGeneral Chemical EngineeringDegeneration (medical)010402 general chemistry01 natural sciencesneurokemialcsh:ChemistryPathogenesis03 medical and health scienceschemistry.chemical_compound0302 clinical medicinemedicinecharacterizationsynteesita116water-soluble cuprizone derivativekemiallinen synteesiin Vitro studiesamiinitChemistryta1182General ChemistryOligodendrocyteIn vitro3. Good health0104 chemical sciencesmedicine.anatomical_structureWater solublelcsh:QD1-999Biochemistryin vitro -menetelmä030217 neurology & neurosurgeryDerivative (chemistry)
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BLBP-expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions

2011

Several lines of evidence indicate that remyelination represents one of the most effective mechanisms to achieve axonal protection. For reasons that are not yet understood, this process is often incomplete or fails in multiple sclerosis (MS). Activated astrocytes appear to be able to boost or inhibit endogenous repair processes. A better understanding of remyelination in MS and possible reasons for its failure is needed. Using the well-established toxic demyelination cuprizone model, we created lesions with either robust or impaired endogenous remyelination capacity. Lesions were analyzed for mRNA expression levels by Affymetrix GeneChip® arrays. One finding was the predominance of immune a…

MalePathologyPlatelet-derived growth factormedicine.medical_treatmentCell CountBehavioral Neurosciencechemistry.chemical_compoundMice0302 clinical medicineFluorescent Antibody Technique IndirectOligonucleotide Array Sequence AnalysisPlatelet-Derived Growth Factor0303 health sciencesGlial fibrillary acidic proteinbiologyExperimental autoimmune encephalomyelitisAstrocytomaMiddle AgedImmunohistochemistrymedicine.anatomical_structureFemaleFibroblast Growth Factor 2Fatty Acid-Binding Protein 7Adultmedicine.medical_specialtyEncephalomyelitis Autoimmune ExperimentalMultiple SclerosisImmunologyBlotting WesternNerve Tissue ProteinsFatty Acid-Binding ProteinsReal-Time Polymerase Chain ReactionTransfection03 medical and health sciencesCuprizoneCell Line TumorGlial Fibrillary Acidic ProteinmedicineAnimalsHumansRNA MessengerRemyelination030304 developmental biologyAgedEndocrine and Autonomic SystemsMultiple sclerosisGrowth factorTumor Suppressor Proteinsmedicine.diseaseOligodendrocyteMice Inbred C57BLchemistryAstrocytesbiology.proteinOsteopontinCarrier Proteins030217 neurology & neurosurgeryDemyelinating Diseases
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CCDC 1846187: Experimental Crystal Structure Determination

2019

Related Article: Martin Fries, Meike Mertens, Nico Teske, Markus Kipp, Cordian Beyer, Thomas Willms, Arto Valkonen, Kari Rissanen, Markus Albrecht, and Tim Clarner|2019|ACS Omega|4|1685|doi:10.1021/acsomega.8b02523

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersN'1N'2-bis(1-methylpiperidin-4-ylidene)ethanedihydrazideExperimental 3D Coordinates
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CCDC 1846185: Experimental Crystal Structure Determination

2019

Related Article: Martin Fries, Meike Mertens, Nico Teske, Markus Kipp, Cordian Beyer, Thomas Willms, Arto Valkonen, Kari Rissanen, Markus Albrecht, and Tim Clarner|2019|ACS Omega|4|1685|doi:10.1021/acsomega.8b02523

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters811-dimethyl-781112-tetraazaspiro[5.6]dodecane-910-dioneExperimental 3D Coordinates
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CCDC 1846186: Experimental Crystal Structure Determination

2019

Related Article: Martin Fries, Meike Mertens, Nico Teske, Markus Kipp, Cordian Beyer, Thomas Willms, Arto Valkonen, Kari Rissanen, Markus Albrecht, and Tim Clarner|2019|ACS Omega|4|1685|doi:10.1021/acsomega.8b02523

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersN'1N'2-dicycloheptylideneethanedihydrazideExperimental 3D Coordinates
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