0000000001306466

AUTHOR

Simona Maria Fiorentino

showing 5 related works from this author

A poly-L-lactic acid/ collagen/glycosaminoglycan matrix for tissue engineering applications

2017

Adhesion of tissue cells to biomaterials is a prerequisite of paramount importance for the effectiveness of a tissue engineering construct (cell and scaffolds). Functionalization of polymeric scaffolds with organic polymers, such as collagen or proteoglycans, is a promising approach in order to improve the cytocompatibility. As a matter of fact, organic polymers, isolated directly from the extracellular matrix, contain a multitude of surface ligand (fibronectin, laminin, vitronectin) and arginine–glycine–aspartic acid-containing peptides that promote cell adhesion. In tissue engineering, the combination of organic and synthetic polymers gives rise to scaffolds characterized simultaneously …

0301 basic medicineMaterials Chemistry2506 Metals and AlloysMaterials sciencePolymers and PlasticsBiocompatibilitypoly-L-lactic acid02 engineering and technologyMatrix (biology)Extracellular matrix03 medical and health sciencesTissue engineeringMaterials ChemistryglycosaminoglycanCell adhesionSettore ING-IND/24 - Principi Di Ingegneria ChimicaPolymers and PlasticPolymer sciencebiologyChemistry (all)General ChemistryAdhesion021001 nanoscience & nanotechnologyBiomaterialFibronectin030104 developmental biologySettore ING-IND/22 - Scienza E Tecnologia Dei Materialitissue engineeringBiophysicsbiology.proteinSurface modificationphase separation0210 nano-technology
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Guar gum/borax hydrogel: Rheological, low field NMR and release characterizations

2013

Guar gum (GG) and Guar gum/borax (GGb) hydrogels are studied by means of rheology, Low Field Nuclear Magnetic Resonance (LF NMR) and model drug release tests. These three approaches are used to estimate the mesh size (ζ) of the polymeric network. A comparison with similar Scleroglucan systems is carried out. In the case of GGb, the rheological and Low Field NMR estimations of ζ lead to comparable results, while the drug release approach seems to underestimate ζ. Such discrepancy is attributed to the viscous effect of some polymeric chains that, although bound to the network to one end, can freely fluctuate among meshes. The viscous drag exerted by these chains slows down drug…

Low field NMRMaterials sciencePolymers and PlasticsField (physics)General Chemical EngineeringDiffusionTransport processeslcsh:Chemical technologyPolymer Gels; Rheology; Low Field NMR; Transport processes; Mesh-sizechemistry.chemical_compoundRheologylcsh:TA401-492Materials ChemistryPolymer Gellcsh:TP1-1185Physical and Theoretical ChemistryComposite materialTransport processeGuar gumBoraxPolymer gelsOrganic ChemistryMesh-sizeLow field nuclear magnetic resonanceLow Field NMRlow field nmr; mesh-size; polymer gels; rheology; transport processesChemical engineeringchemistrySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoSelf-healing hydrogelsViscous effectlcsh:Materials of engineering and construction. Mechanics of materialsRheologyExpress Polymer Letters
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Characterization of PLLA scaffolds for biomedical applications

2017

The porosity and pore size distribution of three-dimensional scaffolds have direct implications on their biomedical applications (tissue engineering, drug delivery, and wound dressing). Accordingly, in this paper, a fast, facile, and conservative method relying on low-field nuclear magnetic resonance (LF-NMR) for the evaluation of mean pore size and pore size distribution of polymeric scaffolds is reported. The applicability of the technique is demonstrated on poly-L-lactic acid scaffolds fabricated using the thermal induced phase separation. Results obtained through LF-NMR are successfully compared to scanning electron microscope and X-ray microcomputed tomography micrographs.

Pore sizeScaffoldMaterials sciencePolymers and PlasticsGeneral Chemical EngineeringNanotechnology02 engineering and technologyscaffold010402 general chemistry01 natural sciencesPLLAAnalytical ChemistryTissue engineeringpore size distributionChemical Engineering (all)PorositySettore ING-IND/24 - Principi Di Ingegneria Chimicaintegumentary systemLow-field NMR; phase separation; PLLA; pore size distribution; scaffold; Analytical Chemistry; Chemical Engineering (all); Polymers and Plastics021001 nanoscience & nanotechnology0104 chemical sciencesCharacterization (materials science)Settore ING-IND/22 - Scienza E Tecnologia Dei MaterialiWound dressingDrug deliveryphase separation0210 nano-technologyLow-field NMR
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Physical characterization of alginate-Pluronic F127 gel for endoluminal NABDs delivery

2014

Here we focus the attention on the physical characteristics of a highly biocompatible hydrogel made up of crosslinked alginate and Pluronic F127 (PF127). This is a composite polymeric blend we propose for artery endoluminal delivery of an emerging class of molecules named nucleic acid based drugs (NABDs). The physical characterization of our composite gel, i.e. mesh size distribution and PF127-alginate mutual organization after crosslinking, can significantly determine the NABDs release kinetics. Thus, to explore these aspects, different technical approaches, i.e. rheology, low/high field NMR and TEM, were used. While rheology provided information at the macroscopic and nano-level, the othe…

Materials sciencegel pavingAlginatesKineticsComposite numberNanotechnologyPoloxamerMicellerestenosisRheologyalginateArterial wallMicellesDrug Carriersgel paving; rheology; NMR; alginate; Pluronic; restenosisGeneral ChemistryPluronicPoloxamerCondensed Matter PhysicsNMRCharacterization (materials science)Chemical engineeringSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoSolute diffusionrheologyNABDs release kinetics PF127 alginate gel paved stent artery endoluminal deliveryGels
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Characterization of PLLA scaffolds for biomedical applications

2020

The porosity and pore size distribution of three-dimensional scaffolds have direct implications on their biomedical applications (tissue engineering, drug delivery, and wound dressing). Accordingly, in this paper, a fast, facile, and conservative method relying on low-field nuclear magnetic resonance (LF-NMR) for the evaluation of mean pore size and pore size distribution of polymeric scaffolds is reported. The applicability of the technique is demonstrated on poly-L-lactic acid scaffolds fabricated using the thermal induced phase separation. Results obtained through LF-NMR are successfully compared to scanning electron microscope and X-ray microcomputed tomography micrographs.

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