Metabolic disorders across hepatocellular carcinoma in Italy

Background: Metabolic disorders are well-known risk factors for HCC. Conversely, their impact on the natural history of HCC is not established. This study aimed at evaluating the impact of metabolic disorders on clinical features, treatment and survival of HCC patients regardless of its aetiology. Methods: We analysed the ITA.LI.CA database regarding 839 HCC patients prospectively collected. The following metabolic features were analysed: BMI, diabetes, arterial hypertension, hypercholesterolaemia and hypertriglyceridaemia. According to these features, patients were divided into 3 groups: 0-1, 2 and 3-5 metabolic features. Results: As compared with patients with 0-1 metabolic features, pati…

The changing scenario of hepatocellular carcinoma in Italy: an update

Background and aims: Epidemiology of hepatocellular carcinoma (HCC) is changing in most areas of the world. This study aimed at updating the changing scenario of aetiology, clinical presentation, management and prognosis of HCC in Italy during the last 15 years. Methods: Retrospective analysis of the Italian Liver Cancer (ITA.LI.CA) database included 6034 HCC patients managed in 23 centres from 2004 to 2018. Patients were divided into three groups according to the date of cancer diagnosis (2004-2008, 2009-2013 and 2014-2018). Results: The main results were: (i) a progressive patient ageing; (ii) a progressive increase of non-viral cases and, particularly, of ‘metabolic’ and ‘metabolic + alc…

Nd:YVO4 crystalline film grown by pulsed laser deposition

Abstract We present the preliminary results obtained in the growth of thin films of Nd-doped YVO4 (YVO) by pulsed laser deposition (PLD) on amorphous substrate. The films were obtained by ablating bulk YVO crystals doped with Nd3+ ions with a Q-switched tripled Nd:YAG laser in a UHV chamber. The samples have been characterized both morphologically (with X-ray diffraction and atomic force microscope measurements) and spectroscopically, by measuring fluorescence spectra and lifetime.

The HERBA trial: a retrospective study on patients (pts) with HER2-positive (HER2+ve) breast cancer (BC) and brain metastases (BMs)

Multicentre Italian study of SARS-CoV-2 infection in children and adolescents, preliminary data as at 10 April 2020

Data on features of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in children and adolescents are scarce. We report preliminary results of an Italian multicentre study comprising 168 laboratory-confirmed paediatric cases (median: 2.3 years, range: 1 day–17.7 years, 55.9% males), of which 67.9% were hospitalised and 19.6% had comorbidities. Fever was the most common symptom, gastrointestinal manifestations were frequent; two children required intensive care, five had seizures, 49 received experimental treatments and all recovered.

Validación de los datos de radiación solar UV del Ozone Monitoring Instrument (OMI) a partir de medidas con base en tierra en la costa mediterránea

<p align="justify">The erythemal UV daily dose (EDD) and the local noon UV Index (UVI) obtained from the Ozone Monitoring Instrument (OMI), on board NASA’s Aura satellite, have been validated for the period 2005-2013 using ground based measurements at 5 different sites in the Mediterranean coast: Murcia, Valencia, Palma de Mallorca, Barcelona and Rome (where only measurements of the local noon UVI were available). Ground based measurements were made using YES UVB-1 radiometers in Murcia, Valencia, Palma de Mallorca and Barcelona, and a Brewer MKIV 067 spectrophotometer in Rome. The results of the validation showed good agreement between the satellite instrument and the ground based me…

Syinthesis and spectroscopic and X-ray structural Characterization of R2Sn(IV)-Oxydiacetate and -Iminoacetate complexes

Pattern of macrovascular invasion in hepatocellular carcinoma

Background and aims: In patients with hepatocellular carcinoma (HCC), macrovascular invasion (MaVI) limits treatment options and decreases survival. Detailed data on the relationship between MaVI extension and patients' characteristics, and its impact on patients' outcome are limited. We evaluated the prevalence and extension of MaVI in a large cohort of consecutive HCC patients, analysing its association with liver disease and tumour characteristics, as well as with treatments performed and patients' survival. Methods: We analysed data of 4774 patients diagnosed with HCC recorded in the Italian Liver Cancer (ITA.LI.CA) database (2008-2018). Recursive partition analysis (RPA) was performed …

The HERBA Study: A Retrospective Multi-Institutional Italian Study on Patients With Brain Metastases From HER2-Positive Breast Cancer

There is no sufficient evidence to establish a standard of care for patients with brain metastases (BM) from HER2Data of 154 patients were retrospectively collected at 14 Italian institutions through a specifically designed database.Median overall survival (OS) was 24.5 months. Patients receiving surgery/stereotactic radiosurgery experienced longer OS compared to those receiving whole-brain radiotherapy or no treatment (33.5 vs. 11.4 months; hazard ratio = 0.34; 95% confidence interval, 0.22-0.52; P .001). Interestingly, whole-brain radiotherapy did not improve OS compared to no treatment (11.4 vs. 9.8 months; hazard ratio = 0.99; 95% confidence interval, 0.62-1.62; P = .99). HER2-targeted …

CCDC 179596: Experimental Crystal Structure Determination

Related Article: H.Jankovics, C.Pettinari, F.Marchetti, E.Kamu, L.Nagy, S.Troyanov, L.Pellerito|2003|J.Inorg.Biochem.|97|370|doi:10.1016/S0162-0134(03)00309-X

CCDC 233991: Experimental Crystal Structure Determination

Related Article: C.Pettinari, F.Marchetti, R.Pettinari, A.Cingolani, E.Rivarola, C.Phillips, J.Tanski, M.Rossi, F.Caruso|2004|Eur.J.Inorg.Chem.||3484|doi:10.1002/ejic.200400225

CCDC 233990: Experimental Crystal Structure Determination

Related Article: C.Pettinari, F.Marchetti, R.Pettinari, A.Cingolani, E.Rivarola, C.Phillips, J.Tanski, M.Rossi, F.Caruso|2004|Eur.J.Inorg.Chem.||3484|doi:10.1002/ejic.200400225

CCDC 233992: Experimental Crystal Structure Determination

Related Article: C.Pettinari, F.Marchetti, R.Pettinari, A.Cingolani, E.Rivarola, C.Phillips, J.Tanski, M.Rossi, F.Caruso|2004|Eur.J.Inorg.Chem.||3484|doi:10.1002/ejic.200400225

CCDC 258719: Experimental Crystal Structure Determination

Related Article: F.Marchetti, M.Pellei, C.Pettinari, R.Pettinari, E.Rivarola, C.Santini, B.W.Skelton, A.H.White|2005|J.Organomet.Chem.|690|1878|doi:10.1016/j.jorganchem.2005.01.067