Uncommon Synchronous Association between Ovarian Carcinoma and Gastrointestinal Stromal Tumor: A Case Study and Literature Review

Background The association of gastrointestinal stromal tumors (GIST) and other cancers is well known, but its synchronous occurrence with gynecological malignancies is very uncommon. Usually, the diagnosis is accidentally established. We describe a patient with GIST and concurrent ovarian cancer and discuss the clinical implications of this finding. Case report A 64-year-old woman with a prior diagnosis of ovarian cancer developed a second recurrence after having undergone two operations and adjuvant chemotherapy. While tumor debulking was performed, a small, nonsuspicious lesion was removed from the greater curvature of the stomach. Histology revealed a GIST. Conclusion The association of …

A Search for IceCube Events in the Direction of ANITA Neutrino Candidates

During the first three flights of the Antarctic Impulsive Transient Antenna (ANITA) experiment, the collaboration detected several neutrino candidates. Two of these candidate events were consistent with an ultra-high-energy up-going air shower and compatible with a tau neutrino interpretation. A third neutrino candidate event was detected in a search for Askaryan radiation in the Antarctic ice, although it is also consistent with the background expectation. The inferred emergence angle of the first two events is in tension with IceCube and ANITA limits on isotropic cosmogenic neutrino fluxes. Here, we test the hypothesis that these events are astrophysical in origin, possibly caused by a po…

IceCube search for neutrinos coincident with compact binary mergers from LIGO-Virgo's first gravitational-wave transient catalog

Using the IceCube Neutrino Observatory, we search for high-energy neutrino emission coincident with compact binary mergers observed by the LIGO and Virgo gravitational-wave (GW) detectors during their first and second observing runs. We present results from two searches targeting emission coincident with the sky localization of each GW event within a 1000 s time window centered around the reported merger time. One search uses a model-independent unbinned maximum-likelihood analysis, which uses neutrino data from IceCube to search for pointlike neutrino sources consistent with the sky localization of GW events. The other uses the Low-Latency Algorithm for Multi-messenger Astrophysics, which …

Characteristics of the diffuse astrophysical electron and Tau neutrino flux with six years of IceCube high energy cascade data

We report on the first measurement of the astrophysical neutrino flux using particle showers (cascades) in IceCube data from 2010-2015. Assuming standard oscillations, the astrophysical neutrinos in this dedicated cascade sample are dominated (∼90%) by electron and tau flavors. The flux, observed in the sensitive energy range from 16 TeV to 2.6 PeV, is consistent with a single power-law model as expected from Fermi-type acceleration of high energy particles at astrophysical sources. We find the flux spectral index to be γ=2.53±0.07 and a flux normalization for each neutrino flavor of φastro=1.66-0.27+0.25 at E0=100 TeV, in agreement with IceCube's complementary muon neutrino results and wit…

From laparoscopic assisted radical vaginal hysterectomy to vaginal assisted laparoscopic radical hysterectomy

Radical hysterectomy with pelvic lymphadenectomy is the standard surgical treatment for patients with early stage cervical cancer. The majority of radical hysterectomies are performed with the open technique. However, laparoscopic, combined laparoscopic and vaginal, and robotic-assisted approaches may also be used. Compared with the abdominal radical hysterectomy (ARH), laparoscopic techniques are associated with less blood loss, shorter hospital stay, better cosmesis, and faster recovery. A further breakthrough in laparoscopic technique can only be made if safety and oncological clearance are comparable with ARH. We describe the technique and results of laparoscopic assisted radical vagina…

HIGH GRADE GLIOMAS AND DIPG

Combined sensitivity to the neutrino mass ordering with JUNO, the IceCube Upgrade, and PINGU

Physical review / D 101(3), 032006 (1-19) (2020). doi:10.1103/PhysRevD.101.032006

Cervical cancer and intraepithelial neoplasia

Cervical cancer is the second most frequent malignancy in women. Infection with high-risk papillomaviruses causes cervical cancer and can be prevented by vaccination. Secondary prevention using cytology and/or human papillomavirus testing successfully decreases the incidence of cancer by detection of cervical intraepithelial neoplasia (CIN). Colposcopy is used to locate CIN and to assure preservation of healthy tissue when removing CIN. Diagnosis of CIN and cancer is based on histopathology. In invasive disease, imaging techniques such as MRI or PET-CT help to assess the locoregional extent of the disease. For staging, the FIGO and TNM system are applied. Laparoscopic staging, especially of…

Computational Techniques for the Analysis of Small Signals in High-Statistics Neutrino Oscillation Experiments

The current and upcoming generation of Very Large Volume Neutrino Telescopes – collecting unprecedented quantities of neutrino events – can be used to explore subtle effects in oscillation physics, such as (but not restricted to) the neutrino mass ordering. The sensitivity of an experiment to these effects can be estimated from Monte Carlo simulations. With the high number of events that will be collected, there is a trade-off between the computational expense of running such simulations and the inherent statistical uncertainty in the determined values. In such a scenario, it becomes impractical to produce and use adequately-sized sets of simulated events with traditional methods, such as M…

White Paper on New Opportunities at the Next-Generation Neutrino Experiments (Part 1: BSM Neutrino Physics and Dark Matter)

The combination of the high intensity proton beam facilities and massive detectors for precision measurements of neutrino oscillation parameters including the charge-parity violating (CPV) phase will open the door to help make beyond the standard model (BSM) physics reachable even in low energy regimes in the accelerator-based experiments. Large-mass detectors with highly precise tracking and energy measurements, excellent timing resolution, and low energy thresholds will enable the searches for BSM phenomena from cosmogenic origin, as well. Therefore, it is also conceivable that BSM topics in the next-generation neutrino experiments could be the dominant physics topics in the foreseeable f…

Constraints on Minute-Scale Transient Astrophysical Neutrino Sources

High-energy neutrino emission has been predicted for several short-lived astrophysical transients including gamma-ray bursts (GRBs), core-collapse supernovae with choked jets, and neutron star mergers. IceCube's optical and x-ray follow-up program searches for such transient sources by looking for two or more muon neutrino candidates in directional coincidence and arriving within 100 s. The measured rate of neutrino alerts is consistent with the expected rate of chance coincidences of atmospheric background events and no likely electromagnetic counterparts have been identified in Swift follow-up observations. Here, we calculate generic bounds on the neutrino flux of short-lived transient so…

Supplementary Material for: Neuroimmunomodulatory Alterations in Non-Lesional Peritoneum Close to Peritoneal Endometriosis

Objectives: An imbalance in the ratio of sensory to sympathetic nerve fibre (NF) density in peritoneal endometriotic lesions (pEL) has recently been demonstrated and leads to the assumption that this preponderance of the sensory pro-inflammatory milieu is a major cause of pain in endometriosis. Therefore, the density of sensory and sympathetic NFs was determined in distal unaffected peritoneum of endometriosis patients to be able to detect possible alterations in unaffected peritoneum. Methods: In serial pEL sections (n = 40), lesional and matching unaffected peritoneum as well as healthy peritoneum (HP) from patients without endometriosis (n = 15) were immunohistochemically analysed to ide…

CCDC 1893945: Experimental Crystal Structure Determination

Related Article: J. Anhäuser, R. Puttreddy, Y. Lorenz, A. Schneider, M. Engeser, K. Rissanen, A. Lützen|2019|Org.Chem.Front.|6|1226|doi:10.1039/C9QO00155G

CCDC 1893943: Experimental Crystal Structure Determination

Related Article: J. Anhäuser, R. Puttreddy, Y. Lorenz, A. Schneider, M. Engeser, K. Rissanen, A. Lützen|2019|Org.Chem.Front.|6|1226|doi:10.1039/C9QO00155G

CCDC 1893944: Experimental Crystal Structure Determination

Related Article: J. Anhäuser, R. Puttreddy, Y. Lorenz, A. Schneider, M. Engeser, K. Rissanen, A. Lützen|2019|Org.Chem.Front.|6|1226|doi:10.1039/C9QO00155G