Asymmetric Allylation/Pauson-Khand Reaction: A Simple Entry to Polycyclic Amines. Application to the Synthesis of Aminosteroid Analogues

2014

Asymmetric allylation of o-iodoarylsulfinylimines has been achieved in high diastereoselectivities. The thus-obtained o-iodoarylhomoallylic sulfinamides participate in a subsequent Sonogashira coupling followed by a diastereoselective intramolecular Pauson-Khand reaction. In this way, tricyclic amines showing a unique benzo-fused indenyl backbone were obtained. The methodology has been applied to the synthesis of amino steroid analogues.

Synthesis and application of β-substituted Pauson-Khand adducts: trifluoromethyl as a removable steering group.

2013

The reaction between alkynes (I) and norbornadiene (II) affords the β-substituted Pauson—Khand adducts (III) as single regioisomers and the trifluoromethyl steering group can be easily removed in the presence of DBU and water.

An Internet-Based Intervention for Depression in Primary Care in Spain: A Randomized Controlled Trial.

2016

Background: Depression is the most prevalent cause of illness-induced disability worldwide. Face-to-face psychotherapeutic interventions for depression can be challenging, so there is a need for other alternatives that allow these interventions to be offered. One feasible alternative is Internet-based psychological interventions. This is the first randomized controlled trial (RCT) on the effectiveness of an Internet-based intervention on depression in primary health care in Spain. Objective: Our aim was to compare the effectiveness of a low-intensity therapist-guided (LITG) Internet-based program and a completely self-guided (CSG) Internet-based program with improved treatment as usual (iTA…

Innentitelbild: Synthesis and Application of β-Substituted Pauson-Khand Adducts: Trifluoromethyl as a Removable Steering Group (Angew. Chem. 20/2013)

2013

Inside Cover: Synthesis and Application of β-Substituted Pauson-Khand Adducts: Trifluoromethyl as a Removable Steering Group (Angew. Chem. Int. Ed. 2…

2013

Asymmetric Synthesis of Fluorinated Monoterpenic Alkaloid Derivatives from Chiral Fluoroalkyl Aldimines via the Pauson‐Khand Reaction

2020

ChemInform Abstract: Asymmetric Allylation/Pauson-Khand Reaction: A Simple Entry to Polycyclic Amines. Application to the Synthesis of Aminosteroid A…

2014

Asymmetric allylation of o-iodoarylsulfinylimines has been achieved in high diastereoselectivities. The thus-obtained o-iodoarylhomoallylic sulfinamides participate in a subsequent Sonogashira coupling followed by a diastereoselective intramolecular Pauson–Khand reaction. In this way, tricyclic amines showing a unique benzo-fused indenyl backbone were obtained. The methodology has been applied to the synthesis of amino steroid analogues.

Pauson-Khand reaction of internal dissymmetric trifluoromethyl alkynes. Influence of the alkene on the regioselectivity.

2014

Abstract: The scope of the Pauson-Khand reaction (PKR) of internal trifluoromethyl alkynes, previously described with norbornadiene, is expanded to norbornene and ethylene. A thorough structural analysis of the resulting PK adducts has been carried out to unveil that α-trifluoromethylcyclopentenones are preferred in all cases, independently of the electronic properties of the alkyne. The regioselectivity observed with norbornadiene and ethylene is higher than in the case of norbornene.

CCDC 989965: Experimental Crystal Structure Determination

2014

Related Article: Santos Fustero, Rubén Lázaro, Nuria Aiguabella, Antoni Riera, Antonio Simón-Fuentes, and Pablo Barrio|2014|Org.Lett.|16|1224|doi:10.1021/ol500142c

CCDC 927146: Experimental Crystal Structure Determination

2013

Related Article: Nuria Aiguabella, Carlos del Pozo, Xavier Verdaguer, Santos Fustero, Antoni Riera|2013|Angew.Chem.,Int.Ed.|52|5355|doi:10.1002/anie.201300907

CCDC 1954729: Experimental Crystal Structure Determination

2020

Related Article: Alberto Llobat, Daniel M. Sedgwick, Albert Cabré, Raquel Román, Natalia Mateu, Jorge Escorihuela, Mercedes Medio‐Simón, Vadim Soloshonok, Jianlin Han, Antoni Riera, Santos Fustero|2020|Adv.Synth.Catal.|362 |1378 |doi:10.1002/adsc.201901504