0000000001314263
AUTHOR
Zsolt Galla
Traceless chirality transfer from a norbornene β-amino acid to pyrimido[2,1-a]isoindole enantiomers
The synthesis of two enantiomeric pairs of pyrimidoisoindoles 9a, 9b and 10a, 10b is reported. During a domino ring-closure reaction, followed by cycloreversion, the chirality of diendo-(−)-(1R,2S,3R,4S)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide [(−)-1] was successfully transfered to heterocycles (+)-9a, (+)-10a, (−)-9b, (−)-10b and (−)-10c. peerReviewed
Traceless chirality transfer from a norbornene β-amino acid to pyrimido[2,1-a]isoindole enantiomers
Abstract The synthesis of two enantiomeric pairs of pyrimidoisoindoles 9a, 9b and 10a, 10b is reported. During a domino ring-closure reaction, followed by cycloreversion, the chirality of diendo-(−)-(1R,2S,3R,4S)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide [(−)-1] was successfully transfered to heterocycles (+)-9a, (+)-10a, (−)-9b, (−)-10b and (−)-10c.
CCDC 1964840: Experimental Crystal Structure Determination
Related Article: Ferenc Miklós, Kristof Bozó, Zsolt Galla, Matti Haukka, Ferenc Fülöp|2017|Tetrahedron:Asymm.|28|1401|doi:10.1016/j.tetasy.2017.07.006
CCDC 1964839: Experimental Crystal Structure Determination
Related Article: Ferenc Miklós, Kristof Bozó, Zsolt Galla, Matti Haukka, Ferenc Fülöp|2017|Tetrahedron:Asymm.|28|1401|doi:10.1016/j.tetasy.2017.07.006
CCDC 1964841: Experimental Crystal Structure Determination
Related Article: Ferenc Miklós, Kristof Bozó, Zsolt Galla, Matti Haukka, Ferenc Fülöp|2017|Tetrahedron:Asymm.|28|1401|doi:10.1016/j.tetasy.2017.07.006
CCDC 1964842: Experimental Crystal Structure Determination
Related Article: Ferenc Miklós, Kristof Bozó, Zsolt Galla, Matti Haukka, Ferenc Fülöp|2017|Tetrahedron:Asymm.|28|1401|doi:10.1016/j.tetasy.2017.07.006