0000000001315185
AUTHOR
Nataliya S. Goulioukina
Exploiting Palladium-Catalyzed Cross-Coupling for the Synthesis of 2-Aryl-Substituted 1-Aminocyclopropylphosphonates
A series of 2-aryl-substituted 1-aminocyclopropylphosphonates containing an additional remote phosphonate group have been synthesized starting from readily accessible dimethyl (1 R *,2 R *)-2-(4-bromophenyl)-1-formamidocyclopropylphosphonate using cross-coupling methodology. Different types of palladium-catalyzed reactions for carbon–carbon and carbon–phosphorus bond formation were realized. In each case the optimum conditions were found to obtain the desired products in high yield in both small- and large-scale experiments.
CCDC 959781: Experimental Crystal Structure Determination
Related Article: Nikolay N. Makukhin, Nataliya S. Goulioukina, Alla G. Bessmertnykh-Lemeune, Stéphane Brandès, Roger Guilard, Irina P. Beletskaya|2015|Synthesis|47|279|doi:10.1055/s-0034-1378673
CCDC 959780: Experimental Crystal Structure Determination
Related Article: Nikolay N. Makukhin, Nataliya S. Goulioukina, Alla G. Bessmertnykh-Lemeune, Stéphane Brandès, Roger Guilard, Irina P. Beletskaya|2015|Synthesis|47|279|doi:10.1055/s-0034-1378673