Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

Crohn Disease (CD) is a complex genetic disorder for which more than 140 genes have been identified using genome wide association studies (GWAS). However, the genetic architecture of the trait remains largely unknown. The recent development of machine learning (ML) approaches incited us to apply them to classify healthy and diseased people according to their genomic information. The Immunochip dataset containing 18,227 CD patients and 34,050 healthy controls enrolled and genotyped by the international Inflammatory Bowel Disease genetic consortium (IIBDGC) has been re-analyzed using a set of ML methods: penalized logistic regression (LR), gradient boosted trees (GBT) and artificial neural ne…

Efficient generation of energetic ions in multi-ion plasmas by radio-frequency heating

We describe a new technique for the efficient generation of high-energy ions with electromagnetic ion cyclotron waves in multi-ion plasmas. The discussed ‘three-ion’ scenarios are especially suited for strong wave absorption by a very low number of resonant ions. To observe this effect, the plasma composition has to be properly adjusted, as prescribed by theory. We demonstrate the potential of the method on the world-largest plasma magnetic confinement device, JET (Joint European Torus, Culham, UK), and the high-magnetic-field tokamak Alcator C-Mod (Cambridge, USA). The obtained results demonstrate efficient acceleration of 3He ions to high energies in dedicated hydrogen–deuterium mixtures.…

The Gaia-ESO Public Spectroscopic Survey

The Gaia-ESO Public Spectroscopic Survey has begun and will obtain high quality spectroscopy of some 100000 Milky Way stars, in the field and in open clusters, down to magnitude 19, systematically covering all the major components of the Milky Way. This survey will provide the first homogeneous overview of the distributions of kinematics and chemical element abundances in the Galaxy. The motivation, organisation and implementation of the Gaia-ESO Survey are described, emphasising the complementarity with the ESA Gaia mission. Spectra from the very first observing run of the survey are presented.

Novel method for determination of tritium depth profiles in metallic samples

Tritium accumulation in fusion reactor materials is considered a serious radiological issue, therefore a lot of effort has been concentrated on the development of radiometric techniques. A novel method, based on gradual dissolution, for the determination of the total tritium content and its depth profiles in metallic samples is demonstrated. This method allows for the measurement of tritium in metallic samples after their exposure to a hydrogen and tritium mixture, tritium containing plasma or after irradiation with neutrons resulting in tritium formation. In this method, successive layers of metal are removed using an appropriate etching agent in the controlled regime and the amount of evo…

Overview of the JET results

Since the installation of an ITER-like wall, the JET programme has focused on the consolidation of ITER design choices and the preparation for ITER operation, with a specific emphasis given to the bulk tungsten melt experiment, which has been crucial for the final decision on the material choice for the day-one tungsten divertor in ITER. Integrated scenarios have been progressed with the re-establishment of long-pulse, high-confinement H-modes by optimizing the magnetic configuration and the use of ICRH to avoid tungsten impurity accumulation. Stationary discharges with detached divertor conditions and small edge localized modes have been demonstrated by nitrogen seeding. The differences in…

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

Abstract Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in su…

Multimessenger search for sources of gravitational waves and high-energy neutrinos: Initial results for LIGO-Virgo and IceCube

Made available in DSpace on 2022-04-29T07:21:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-11-17 We report the results of a multimessenger search for coincident signals from the LIGO and Virgo gravitational-wave observatories and the partially completed IceCube high-energy neutrino detector, including periods of joint operation between 2007-2010. These include parts of the 2005-2007 run and the 2009-2010 run for LIGO-Virgo, and IceCube's observation periods with 22, 59 and 79 strings. We find no significant coincident events, and use the search results to derive upper limits on the rate of joint sources for a range of source emission parameters. For the optimistic assumption of …

Comparison of the structure of the plasma-facing surface and tritium accumulation in beryllium tiles from JET ILW campaigns 2011-2012 and 2013-2014

In this study, beryllium tiles from Joint European Torus (JET) vacuum vessel wall were analysed and compared regarding their position in the vacuum vessel and differences in the exploitation conditions during two campaigns of ITER-Like-Wall (ILW) in 2011-2012 (ILW1) and 2013-2014 (ILW2) Tritium content in beryllium samples were assessed. Two methods were used to measure tritium content in the samples - dissolution under controlled conditions and tritium thermal desorption. Prior to desorption and dissolution experiments, scanning electron microscopy and energy dispersive x-ray spectroscopy were used to study structure and chemical composition of plasma-facing-surfaces of the beryllium sampl…

Search for intermediate mass black hole binaries in the first and second observing runs of the Advanced LIGO and Virgo network

Gravitational wave astronomy has been firmly established with the detection of gravitational waves from the merger of ten stellar mass binary black holes and a neutron star binary. This paper reports on the all-sky search for gravitational waves from intermediate mass black hole binaries in the first and second observing runs of the Advanced LIGO and Virgo network. The search uses three independent algorithms: two based on matched filtering of the data with waveform templates of gravitational wave signals from compact binaries, and a third, model-independent algorithm that employs no signal model for the incoming signal. No intermediate mass black hole binary event was detected in this sear…

GW190412: Observation of a binary-black-hole coalescence with asymmetric masses

LIGO Scientific Collaboration and Virgo Collaboration: et al.

Abstracts — Second Symposium on Upper Paleolithic

Overview of the JET results with the ITER-like wall

Following the completion in May 2011 of the shutdown for the installation of the beryllium wall and the tungsten divertor, the first set of JET campaigns have addressed the investigation of the retention properties and the development of operational scenarios with the new plasma-facing materials. The large reduction in the carbon content (more than a factor ten) led to a much lower Zeff (1.2-1.4) during L- and H-mode plasmas, and radiation during the burn-through phase of the plasma initiation with the consequence that breakdown failures are almost absent. Gas balance experiments have shown that the fuel retention rate with the new wall is substantially reduced with respect to the C wall. T…

Search for Gravitational Waves Associated with Gamma-Ray Bursts Detected by Fermi and Swift during the LIGO-Virgo Run O3a

Abbott, R., et al. (LIGO and VIRGO Collaboration)

Search for Gravitational-wave Signals Associated with Gamma-Ray Bursts during the Second Observing Run of Advanced LIGO and Advanced Virgo

We present the results of targeted searches for gravitational-wave transients associated with gamma-ray bursts during the second observing run of Advanced LIGO and Advanced Virgo, which took place from 2016 November to 2017 August. We have analyzed 98 gamma-ray bursts using an unmodeled search method that searches for generic transient gravitational waves and 42 with a modeled search method that targets compact-binary mergers as progenitors of short gamma-ray bursts. Both methods clearly detect the previously reported binary merger signal GW170817, with p-values of <9.38 10-6 (modeled) and 3.1 10-4 (unmodeled). We do not find any significant evidence for gravitational-wave signals associate…

A Fermi Gamma-Ray Burst Monitor Search for Electromagnetic Signals Coincident with Gravitational-wave Candidates in Advanced LIGO's First Observing Run

We present a search for prompt gamma-ray counterparts to compact binary coalescence gravitational wave (GW) candidates from Advanced LIGO's first observing run (O1). As demonstrated by the multimessenger observations of GW170817/GRB 170817A, electromagnetic and GW observations provide complementary information about the astrophysical source and, in the case of weaker candidates, may strengthen the case for an astrophysical origin. Here we investigate low-significance GW candidates from the O1 compact-binary coalescence searches using the Fermi Gamma-ray Burst Monitor (GBM), leveraging its all-sky and broad energy coverage. Candidates are ranked and compared to background to measure signific…

Modelling of JET hybrid plasmas with emphasis on performance of combined ICRF and NBI heating

International audience; During the 2015--2016 JET campaigns, many efforts have been devoted to the exploration of high-performance plasma scenarios envisaged for DT operation in JET. In this paper, we review various key recent hybrid discharges and model the combined ICRF NBI heating. These deuterium discharges with deuterium beams had the ICRF antenna frequency tuned to match the cyclotron frequency of minority H at the centre of the tokamak coinciding with the second harmonic cyclotron resonance of D. The modelling takes into account the synergy between ICRF and NBI heating through the second harmonic cyclotron resonance of D beam ions, allowing us to assess its impact on the neutron rate…

Search for GW signals associated with GRBs

We present the results of targeted searches for gravitational-wave transients associated with gamma-ray bursts during the second observing run of Advanced LIGO and Advanced Virgo, which took place from 2016 November to 2017 August. We have analyzed 98 gamma-ray bursts using an unmodeled search method that searches for generic transient gravitational waves and 42 with a modeled search method that targets compact-binary mergers as progenitors of short gamma-ray bursts. Both methods clearly detect the previously reported binary merger signal GW170817, with p-values of <9.38x10^-6^ (modeled) and 3.1x10^-4^ (unmodeled). We do not find any significant evidence for gravitational-wave signals assoc…