Il montaggio del dettaglio. Nuove concezioni dello spazio in architettura

Durante gli ultimi venti anni, l'architettura contemporanea ha visto emergere un nuovo approccio dello spazio costruito, relativo alle nozioni di involucro, al principio di smaterializzazione della facciata, di traslucidità, che ha determinato nuove codificazioni dello spazio interno dell'edificio e che ha contribuito a ridefinire le relazioni di quest'ultimo all’intorno urbano ed alla città. Interrogarsi sulle origini e le modalità di definizione di tale approccio nella concezione e nella costruzione dell'edificio conduce ad identificare una tematica complessa, in cui il ruolo svolto dalle nuove teorie che riguardano lo spazio costruito e la sua percezione è indissociabile da quello dei pr…

Amyloid beta-peptide aggregation and interaction with yeast cells membranes

Protein misfolding, aggregation and conversation...

Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans.

By combining all the data available from the Genetic Analysis of Multiple sclerosis in EuropeanS (GAMES) project, we have been able to identify 17 microsatellite markers showing consistent evidence for apparent association. As might be expected five of these markers map within the Major Histocompatibility Complex (MHC) and are in LD with HLA-DRB1. Individual genotyping of the 12 non-MHC markers confirmed association for three of them — D11S1986, D19S552 and D20S894. Association mapping across the candidate genes implicated by these markers in 937 UK trio families revealed modestly associated haplotypes in JAG1 (p=0.019) on chromosome 20p12.2 and POU2AF1 (p=0.003) on chromosome 11q23.1.

Higher Fluid Balance Increases the Risk of Death From Sepsis: Results From a Large International Audit

Contains fulltext : 177598.pdf (Publisher’s version ) (Closed access) OBJECTIVES: Excessive fluid therapy in patients with sepsis may be associated with risks that outweigh any benefit. We investigated the possible influence of early fluid balance on outcome in a large international database of ICU patients with sepsis. DESIGN: Observational cohort study. SETTING: Seven hundred and thirty ICUs in 84 countries. PATIENTS: All adult patients admitted between May 8 and May 18, 2012, except admissions for routine postoperative surveillance. For this analysis, we included only the 1,808 patients with an admission diagnosis of sepsis. Patients were stratified according to quartiles of cumulative f…

Progressive right ventricular dysfunction and exercise impairment in patients with heart failure and diabetes mellitus: insights from the T.O.S.CA. Registry

Abstract Background Findings from the T.O.S.CA. Registry recently reported that patients with concomitant chronic heart failure (CHF) and impairment of insulin axis (either insulin resistance—IR or diabetes mellitus—T2D) display increased morbidity and mortality. However, little information is available on the relative impact of IR and T2D on cardiac structure and function, cardiopulmonary performance, and their longitudinal changes in CHF. Methods Patients enrolled in the T.O.S.CA. Registry performed echocardiography and cardiopulmonary exercise test at baseline and at a patient-average follow-up of 36 months. Patients were divided into three groups based on the degree of insulin impairmen…

Aspirin for preventing the recurrence of venous thromboembolism

Oligomerization of Concanavalin A in live cells detected by fluctuation analysis.

Il Paesaggio agricolo nella Conca d'Oro di Palermo