6533b7cefe1ef96bd1256ef3
RESEARCH PRODUCT
Intestinal conversion of linoleic acid to arachidonic acid in the rat
A. BernardA. BernardJean Paul BlondJean Paul BlondC. CaselliC. CaselliH. CarlierH. CarlierPhilippe BesnardPhilippe Besnardsubject
chemistry.chemical_classificationNutrition and DieteticsEnterocyteEndocrinology Diabetes and MetabolismLinoleic acidClinical BiochemistryBiologyBiochemistryIntestinal absorptionchemistry.chemical_compoundmedicine.anatomical_structurechemistryIntestinal mucosaBiochemistrymedicineArachidonic acidLymphDigestionMolecular BiologyPolyunsaturated fatty aciddescription
Abstract The arachidonic acid (C20:4, n-6) appearing in intestinal lymph during linoleic acid (C18:2, n-6) absorption may originate from enterocyte synthesis or from the liver either after secretion in biliary phospholipids at the same time dietary linoleic acid absorption occurs or via plasma. The radioactivity measured in the total bile collected during the 6 hours of linoleic acid absorption is too small to explain hepatic origin of the C20:4 detected by high performance liquid chromatography analysis of labeled fatty acids recovered in the lymph, in the intestinal mucosa, and the intestinal wall at the peak of linoleic acid intestinal absorption. This study confirms the probability that under in vivo conditions, during the absorption processes, rat intestine is able to convert dietary linoleic acid independent of liver desaturases and elongase activities.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1993-11-01 | The Journal of Nutritional Biochemistry |