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RESEARCH PRODUCT
Sleep–wake problems in patients with amyotrophic lateral sclerosis: implications for patient management
Rossella SpataroEmanuele CannizzaroAlfonsa Claudia TaielloVincenzo La BellaDaniele Lo Cocosubject
medicine.medical_specialtybusiness.industrymedicine.diseasePhysical medicine and rehabilitationExcessive daytime somnolencemedicineInsomniaNocturiaAnxietyNeurology (clinical)Restless legs syndromemedicine.symptomAmyotrophic lateral sclerosisChokingbusinessDepression (differential diagnoses)description
SUMMARY Sleep–wake problems are frequent, although unrecognized, complications of amyotrophic lateral sclerosis (ALS). Sleep disorders such as insomnia, sleep-disordered breathing and restless legs syndrome have all been reported in patients with ALS, despite the limited number of studies and the small populations investigated so far. Sleep disturbances gradually worsen with disease progression, suggesting a relationship between the severity of disease and the neurodegenerative process. However, poor sleep can also be a consequence of several disturbances such as anxiety, depression, pain, choking, sialorrhea, fasciculations, cramps, nocturia and the inability to get comfortable and move freely in bed. Sleep disorders may have many reflections on patients with ALS, including excessive daytime somnolence, fatigue, impaired cognition, reduced quality of life and survival. This article reviews the recent literature on sleep–wake problems in patients with ALS, focusing on the implications for patient management.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-06-01 | Neurodegenerative Disease Management |