6533b7cefe1ef96bd1257076

RESEARCH PRODUCT

Atherogenic dyslipidemia and oxidative stress: a new look

Giovam Battista RiniVesna Spasojevic-kalimanovskaJelena Kotur-stevuljevicManfredi RizzoGiatgen A. SpinasZorana Jelic-ivanovicJelena VekicKaspar Berneis

subject

medicine.medical_specialty10265 Clinic for Endocrinology and Diabetology610 Medicine & healthOxidative phosphorylation030204 cardiovascular system & hematology2704 Biochemistry (medical)medicine.disease_causeAtherogenic dyslipidemia oxidative stressCoronary artery disease03 medical and health sciences2737 Physiology (medical)0302 clinical medicinePhysiology (medical)Internal medicineHumansMedicineDyslipidemias030304 developmental biologySubclinical infectionchemistry.chemical_classification0303 health sciencesReactive oxygen speciesAtherogenic dyslipidemiabusiness.industryVascular diseaseBiochemistry (medical)Public Health Environmental and Occupational HealthAtherogenic dyslipidemia2739 Public Health Environmental and Occupational HealthGeneral MedicineAtherosclerosismedicine.disease3. Good healthLipoproteins LDLOxidative StressEndocrinologychemistrybusinessOxidized ldlOxidative stress

description

Although results from in vitro studies and clinical trials demonstrate strong associations between oxidative stress and cardiovascular risk, to date still no convincing data are available to suggest that treatment with antioxidants might reduce vascular events. Oxidative modifications of low-density lipoproteins (LDL) represent an early stage of atherosclerosis, and small, dense LDL are more susceptible to oxidation than larger, more buoyant particles. Oxidized LDL are independent predictors of subclinical and clinical atherosclerosis. Recent studies suggested that novel therapeutic strategies may take into account the removal of such particles from circulation. Future research is required to explore the potential synergistic impact of markers of oxidative stress and atherogenic dyslipidemia, particularly small dense LDL, on cardiovascular risk. (Translational Research 2009; 153:217-223)

yearjournalcountryeditionlanguage
2009-01-01Translational Research
https://doi.org/10.1016/j.trsl.2009.01.008