6533b7cefe1ef96bd1257199
RESEARCH PRODUCT
Micro- to Nanoscale Bio-Hybrid Hydrogels Engineered by Ionizing Radiation
DispenzaCleliaGiacomazzaDanielaJonssonMatssubject
Materials sciencePolymerslcsh:QR1-502Nanotechnology02 engineering and technologyReview010402 general chemistry01 natural sciencesBiochemistrylcsh:MicrobiologyIonizing radiationradiation chemistrymicro-/nano-gel patternsHydrophilic polymersnanogelsTissue engineeringRadiation Ionizingradiation chemistry; micro-/nano-gel patterns; nanogels; bio-hybrid hydrogels; drug delivery; tissue engineeringMolecular BiologyNanoscopic scalechemistry.chemical_classificationBiomoleculeHydrogelsPolymer021001 nanoscience & nanotechnology0104 chemical scienceschemistrytissue engineeringSelf-healing hydrogelsDrug deliverydrug deliveryNanoparticlesbio-hybrid hydrogelsSettore CHIM/07 - Fondamenti Chimici Delle Tecnologie0210 nano-technologydescription
Bio-hybrid hydrogels consist of a water-swollen hydrophilic polymer network encapsulating or conjugating single biomolecules, or larger and more complex biological constructs like whole cells. By modulating at least one dimension of the hydrogel system at the micro- or nanoscale, the activity of the biological component can be extremely upgraded with clear advantages for the development of therapeutic or diagnostic micro- and nano-devices. Gamma or e-beam irradiation of polymers allow a good control of the chemistry at the micro-/nanoscale with minimal recourse to toxic reactants and solvents. Another potential advantage is to obtain simultaneous sterilization when the absorbed doses are within the sterilization dose range. This short review will highlight opportunities and challenges of the radiation technologies to produce bio-hybrid nanogels as delivery devices of therapeutic biomolecules to the target cells, tissues, and organs, and to create hydrogel patterns at the nano-length and micro-length scales on surfaces.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-01-01 |