6533b7cefe1ef96bd125727d

RESEARCH PRODUCT

Cation exchange-based post-processing of 68Ga-eluate: A comparison of three solvent systems for labelling of DOTATOC, NO2APBP and DATAm

Frank RoeschJohanna SeemannTobias L. RossBradley WaldronElisabeth Eppard

subject

Solvent systemchemistry.chemical_compoundReproducibilityRadiationChromatographyEthanolchemistryElutionYield (chemistry)LabellingAcetoneIon-exchange resin

description

Interest in (68)Ga has led to a number of innovations for its provision suitable for clinical application. Several post-processing methods are available to reduce eluate volume and remove metal trace impurities. In this work three cation exchange resin based post-processing methods (acetone, ethanol and NaCl) have been compared, using three model precursors (DOTATOC, NO2AP(BP) and DATA(m)), in terms of labelling yield and reproducibility. The acetone and ethanol based methods provided greater reproducibility and yields that makes subsequent purification unnecessary.

yearjournalcountryeditionlanguage
2014-06-29Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2015.01.023