6533b7cefe1ef96bd1257292
RESEARCH PRODUCT
Protein corona composition of poly(ethylene glycol)- and poly(phosphoester)-coated nanoparticles correlates strongly with the amino acid composition of the protein surface
Giovanni SettanniJiajia ZhouFriederike SchmidSusanne SchöttlerVolker MailänderTongchuan SuoKatharina Landfestersubject
Materials scienceNanoparticleProtein Corona02 engineering and technologyMolecular Dynamics Simulation010402 general chemistry01 natural sciencesPolyethylene Glycolschemistry.chemical_compoundMolecular dynamicsAdsorptionPolymer chemistryPEG ratioHumansMoleculeGeneral Materials ScienceAmino Acidstechnology industry and agricultureBlood Proteins021001 nanoscience & nanotechnology0104 chemical scienceschemistryNanoparticlesProtein CoronaAdsorption0210 nano-technologyEthylene glycolProtein adsorptiondescription
Extensive molecular dynamics simulations reveal that the interactions between proteins and poly(ethylene glycol) (PEG) can be described in terms of the surface composition of the proteins. PEG molecules accumulate around non-polar residues while avoiding the polar ones. A solvent-accessible-surface-area model of protein adsorption accurately fits a large set of data on the composition of the protein corona of poly(ethylene glycol)- and poly(phosphoester)-coated nanoparticles recently obtained by label-free proteomic mass spectrometry.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-27 | Nanoscale |