6533b7cefe1ef96bd12572bf
RESEARCH PRODUCT
REM sleep behavior disorder in a patient with frontotemporal dementia
Valentina BaiamonteEmanuele CannizzaroAlfredo MattalianoChiara CupidiSabrina RealmutoDaniele Lo Cocosubject
Malemedicine.medical_specialtyNeurologyREM Sleep Behavior DisorderDermatologyPolysomnographyAudiologySettore BIO/09 - FisiologiaREM sleep behavior disorderMuscle tonemental disordersmedicineHumansPsychiatryAgedSleep disordermedicine.diagnostic_testElectromyographyREM sleep behaviorGeneral MedicineParasomniamedicine.diseaseElectrooculographyPsychiatry and Mental healthmedicine.anatomical_structureFrontotemporal DementiaSettore BIO/14 - FarmacologiaSettore MED/26 - NeurologiaNeurology (clinical)TauopathyPsychologyFrontotemporal dementiadescription
We describe a patient with frontotemporal dementia (FTD), a tauopathy, who also showed clinical and polysomnographic features of REM sleep behavior disorder (RBD). The patient is a 78-year-old male with a 1 year history of behavioral dysfunction involving emotion, character and social functioning. Brain imaging and the results of neuropsychological testing were consistent with a diagnosis of FTD. Sleep symptom onset occurred some years before the behavioral changes, and consisted of unpleasant dreams, vocalization, and prominent motor behaviors. A polysomnography confirmed the diagnosis of RBD. Our findings support the hypothesis that RBD, although more frequent in synucleinopathies, might be a pathological stage in the development of almost every neurodegenerative disorder in which the pathological process involves the cerebral structures that regulate muscle tone during REM sleep.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-11-08 | Neurological Sciences |