6533b7cefe1ef96bd1257ba7

RESEARCH PRODUCT

Dihydrophenanthrenes from a Sicilian Accession of Himantoglossum robertianum (Loisel.) P. Delforge Showed Antioxidant, Antimicrobial, and Antiproliferative Activities

Natale BadalamentiSabino RussiMaurizio BrunoViviana MarescaAlessandro VaglicaVincenzo IlardiAnna ZanfardinoMichela Di NapoliMario VarcamontiPiergiorgio CianciulloGiovanni CaliceSimona LaurinoGeppino FalcoAdriana Basile

subject

dihydrophenanthrenes; <i>Himantoglossum robertianum</i>; NMR; antioxidant enzymes; antimicrobial activity; anti-proliferative activity; proapoptotic activityantimicrobial activityantioxidant enzymeEcologyproapoptotic activityBotany<i>Himantoglossum robertianum</i>Plant SciencedihydrophenanthreneNMRHimantoglossum robertianumQK1-989anti-proliferative activityAntioxidant enzymesEcology Evolution Behavior and SystematicsDihydrophenanthrenes

description

The peculiar aspect that emerges from the study of Orchidaceae is the presence of various molecules, which are particularly interesting for pharmaceutical chemistry due to their wide range of biological resources. The aim of our study was to investigate the properties of two dihydrophenanthrenes, isolated, for the first time, from Himantoglossum robertianum (Loisel.) P. Delforge (Orchidaceae) bulbs and roots. Chemical and spectroscopic study of the bulbs and roots of Himantoglossumrobertianum (Loisel.) P. Delforge resulted in the isolation of two known dihydrophenanthrenes—loroglossol and hircinol—never isolated from this plant species. The structures were evaluated based on 1H-NMR, 13C-NMR, and two-dimensional spectra, and by comparison with the literature. These two molecules have been tested for their possible antioxidant, antimicrobial, antiproliferative, and proapoptotic activities. In particular, it has been shown that these molecules cause an increase in the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione S-transferase (GST) in polymorphonuclear leukocytes (PMN); show antimicrobial activity against Escherichia coli and Staphylococcus aureus, and have anti-proliferative effects on gastric cancer cell lines, inducing apoptosis effects. Therefore, these two molecules could be considered promising candidates for pharmaceutical and nutraceutical preparations.

yearjournalcountryeditionlanguage
2021-12-15Plants
https://doi.org/10.3390/plants10122776