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RESEARCH PRODUCT

Simultaneous dissolution profiles of two drugs, sulfadiazine-trimethoprim and amitriptyline-perphenazine, in solid oral dosage forms by a FIA manifold provided with a single spectrophotometric detector

J. Martínez CalatayudJ. V. García MateoA Moreno Gálvez

subject

PerphenazineAmitriptylineClinical BiochemistryAnalytical chemistryAdministration OralSulfadiazinePharmaceutical ScienceDerivativeTrimethoprimDosage formAnalytical ChemistrySpectrophotometryDrug DiscoverymedicineDissolutionSpectroscopyDosage FormsFlow injection analysisAmitriptyline/perphenazineChromatographymedicine.diagnostic_testChemistryDetectorDrug CombinationsSolubilitySpectrophotometryFlow Injection AnalysisPerphenazinemedicine.drug

description

The simultaneous determination of two dissolution profiles with the aid of a Flow Injection Analysis assembly has been applied to: (a) sulfadiazine-trimethoprim in tablets and (b) amitriptyline-perphenazine in sugar coated pills. The selected combinations are drugs which have overlapping UV-vis spectra. The officially proposed procedure from the pharmacopoeias has been adapted for the FIA methodology and derivative spectrophotometry and zero crossing. Preliminary experiments on the suitability of the simultaneous determination of both drugs were performed. The empirical profiles were adjusted by regression analysis using different approaches. The 3-parameter plot method was finally selected as the most suitable for the sulfadiazine-trimethoprim and the 4-parameter equation plot for amitriptyline-perphenazine.

yearjournalcountryeditionlanguage
2002-10-09Journal of Pharmaceutical and Biomedical Analysis
https://doi.org/10.1016/s0731-7085(02)00316-3