6533b7cffe1ef96bd1258c89

RESEARCH PRODUCT

P0926 : Representation of human non-alcoholic fatty liver disease in murine models

Felix StickelX.-y. WangAndreas TeufelW Von SchönfelsA HerrmannStephan I. BrücknerTriantafyllos ChavakisThomas BeckerStefan SchreiberJochen HampeClemens SchafmayerDetlef SchuppanMario BroschT. ItzelW. ErhardtClaus HellerbrandYong Ook Kim

subject

HepatologyDDX5Mechanism (biology)Fatty liverBiologymedicine.diseaseCell biologyInsulin receptorchemistry.chemical_compoundDownregulation and upregulationchemistrymicroRNAbiology.proteinmedicineDroshaPI3K/AKT/mTOR pathway

description

COX-2 enhances insulin signaling. Finally, the relationship between COX-2 and the miRNAs was confirmed in NAS. Conclusions: COX-2 represses the expression of miRNAs implicated in the insulin signaling pathway via a PI3K/p300-dependent upregulation of DDX5, and by modulating the activity of the Drosha complex. Our study proposes a novel miRNA-dependent mechanism through which COX-2 promotes insulin signaling in liver cells.

yearjournalcountryeditionlanguage
2015-04-01Journal of Hepatology
https://doi.org/10.1016/s0168-8278(15)31128-4