6533b7cffe1ef96bd1259034

RESEARCH PRODUCT

Neoclerodane Diterpenoids from Teucrium massiliense

Giuseppe SavonaDe La Torre McBenjamín RodríguezMariapia PaternostroGianfranco Fontana

subject

Pharmacologychemistry.chemical_compoundComplementary and alternative medicineChemistryStereochemistryOrganic ChemistryDrug DiscoveryPharmaceutical ScienceMolecular MedicineTeucrium massilienseDiterpeneTerpenoidAnalytical Chemistry

description

A reinvestigation of the diterpene metabolites of Teucrium massiliense L. allowed the isolation of four new neoclerodane derivatives, teumassilenins A-D, together with all the diterpenoids previously reported as constituents of this plant. The structures of the new compounds (1-4) were established by chemical and spectroscopic means. A plausible biogenetic relationship between several of these substances is briefly discussed, and some unpublished physical and spectroscopic data of the previously known diterpenoid teumassin (5) are now reported.

https://doi.org/10.1021/np980137r