6533b7cffe1ef96bd12598b8
RESEARCH PRODUCT
Self-adjuvanting synthetic antitumor vaccines from MUC1 glycopeptides conjugated to T-cell epitopes from tetanus toxoid.
Hui CaiYufen ZhaoHorst KunzYan-mei LiMei-sha ChenZhan-yi Sunsubject
medicine.drug_classmedicine.medical_treatmentEpitopes T-Lymphocytecomplex mixturesImmunostimulantCancer VaccinesCatalysisEpitopeEpitopesImmune systemmedicineTetanus ToxoidHumansTetanusChemistryMucin-1ToxoidGlycopeptidesGeneral Chemistrymedicine.diseaseVirologyComplement-dependent cytotoxicityGlycopeptideEpitopes B-LymphocytePeptidesAdjuvantdescription
The T-helper epitope peptide P30 (green in the scheme) from tetanus toxoid was used as the immunostimulant in MUC1 glycopeptide antitumor vaccines and apparently also acts as a built-in adjuvant. P30-conjugated glycopeptide vaccines containing three glycans in the immunodominant motifs PDTRP and GSTAP induced much stronger immune responses and complement dependent cytotoxicity mediated killing of tumor cells when applied in plain PBS solution without complete Freund's adjuvant.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-04-24 | Angewandte Chemie (International ed. in English) |