6533b7cffe1ef96bd1259aa5
RESEARCH PRODUCT
Changes in serum fetuin-A and inflammatory markers levels in end-stage renal disease (ESRD): effect of a single session haemodialysis.
Riccardo Di SciaccaMaurizio Li VecchiGiulia BivonaChiara BelliaRossella IatrinoEpifanio Di NataleMarcello Ciacciosubject
Malemedicine.medical_specialtymedicine.medical_treatmentClinical BiochemistryInflammationFibrinogenEnd stage renal diseaseRenal DialysisInternal medicinemedicineHumansAgedbusiness.industryBiochemistry (medical)Acute-phase proteinAlbuminGeneral MedicineMiddle Agedmedicine.diseaseFetuinEndocrinologyKidney Failure ChronicFemaleHemodialysisalpha-Fetoproteinsmedicine.symptomInflammation MediatorsbusinessKidney diseasemedicine.drugdescription
Background: The aim of the present study was to evaluate the effect of a single haemodialysis (HD) session on serum fetuin-A levels, considered a negative acute phase response marker; moreover, we evaluated the behaviour of fibrinogen and high sensitivity C-reactive protein (hsCRP) as acute phase response and chronic/subclinical inflammation markers, respectively, after a single HD session. Methods: Serum fetuin-A, albumin, hsCRP and fibrinogen were measured in 72 patients before and after a single HD session. Results: After a single HD session, we observed a significant increase in fibrinogen levels, while fetuin-A levels decreased (p<0.05). Also, hsCRP levels were significantly increased. Conclusions: The significant decrease of fetuin-A levels after a single HD session is consistent with the hypothesis of HD-induced inflammation; activated acute phase response and fetuin-A deficiency might account for increased cardiovascular risk and accelerated atherogenesis in dialysis patients.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-12-14 | Clinical chemistry and laboratory medicine |