6533b7d0fe1ef96bd125a39d

RESEARCH PRODUCT

EGFR and PCNA experession in oral squamous cell carcinomas—a valuable tool in estimating the patient's prognosis

K.a. ReiffenT. ReichertWilfried WagnerStephan Störkel

subject

AdultCancer ResearchPathologymedicine.medical_specialtyMalignancyAntigenPredictive Value of TestsEpidermal growth factorProliferating Cell Nuclear AntigenBiomarkers TumormedicineHumansNeoplasm InvasivenessProspective StudiesEpidermal growth factor receptorSurvival analysisNeoplasm StagingMouth neoplasmbiologyPrognosismedicine.diseaseImmunohistochemistrySurvival AnalysisProliferating cell nuclear antigenErbB ReceptorsGene Expression Regulation Neoplasticstomatognathic diseasesTreatment OutcomeOncologyCarcinoma Squamous CellCancer researchbiology.proteinImmunohistochemistryMouth Neoplasms

description

We investigated 100 cases of oral squamous cell carcinomas immunohistologically with respect to the expression of the epidermal growth factor receptor (EGFR) and the proliferating cell nuclear antigen (PCNA). The results were correlated with a new malignancy grading of the invasive tumour areas and the clinical outcome of the patients to estimate the individual prognosis. In conclusion, the amount of antigen expression of both antigens increases with the increasing grade of malignancy of the oral squamous cell carcinoma. Furthermore, there is a statistically significant correlation between the amount of antigen expression and the patient's prognosis. An overexpression of EGFR and PCNA is associated with a short survival of the patient. Both antigens detect relevant tumour biological parameters and are worthy factors in estimating the individual prognosis in patients suffering from oral squamous cell carcinomas.

yearjournalcountryeditionlanguage
1993-10-01European Journal of Cancer Part B: Oral Oncology
https://doi.org/10.1016/0964-1955(93)90047-i