PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation

6533b7d0fe1ef96bd125a513

RESEARCH PRODUCT

PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation

Marcos Henrique Rosa Miriam M. Fonseca Juliana E Toller-kawahisa Fernando Silva Ramalho Douglas Silva Prado Gabriel Azevedo Publio Timna Varela Martins Luis Eduardo Alves Damasceno Flávio P. Veras Thiago M. Cunha Ari Waisman José C. Alves-filho Fernando Q. Cunha

subject

STAT3 Transcription Factor 0301 basic medicine Encephalomyelitis Autoimmune Experimental Cellular differentiation Encephalomyelitis Pyruvate Kinase Immunology Fluorescent Antibody Technique Autoimmunity Inflammation PKM2 Real-Time Polymerase Chain Reaction Article Mice 03 medical and health sciences 0302 clinical medicine Neuroinflammation medicine Animals Immunology and Allergy STAT3 Inflammation biology Chemistry Experimental autoimmune encephalomyelitis Cell Differentiation hemic and immune systems Flow Cytometry medicine.disease Cell biology Mice Inbred C57BL 030104 developmental biology Tumor progression 030220 oncology & carcinogenesis biology.protein Th17 Cells medicine.symptom REAÇÃO EM CADEIA POR POLIMERASE Pyruvate kinase

description

Th17 cells undergo metabolic reprogramming towards glycolysis to support their differentiation and pathogenicity. Damasceno et al. report that PKM2, a glycolytic enzyme, plays a nonmetabolic role in mediating Th17 cell differentiation and autoimmune neuroinflammation by fine-tuning STAT3 activation.

year	journal	country	edition	language
2019-04-05	Journal of Experimental Medicine

https://doi.org/10.1084/jem.20190613

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