6533b7d0fe1ef96bd125a55f

RESEARCH PRODUCT

Potential Non-Invasive Biomarkers for Early Diagnosis of Oral Squamous Cell Carcinoma

Valentina DikovaJose V. BaganEloisa Jantus-lewintre

subject

Salivamedicine.medical_specialtynon-invasive biomarkerslcsh:MedicineDiseaseGastroenterologyArticleoral leukoplakia03 medical and health sciences0302 clinical medicinesaliva testingSaliva testingInternal medicineMedicineBasal cellmedicine.diagnostic_testbusiness.industrylcsh:RNon invasive biomarkersArea under the curve030206 dentistryGeneral Medicineoral cancer3. Good healthOral leukoplakiastomatognathic diseasestranslational research030220 oncology & carcinogenesisImmunoassaybusiness

description

This study aimed to investigate the role of a panel of salivary cytokines as biomarkers for early detection oral squamous cell carcinoma (OSCC), comparing their levels among healthy individuals, patients with oral leukoplakia (OL), and malignant lesions. Cytokine profiling analysis performed in a minimally invasive sample was correlated with clinicopathological variables in our patient cohorts. Unstimulated saliva was obtained from subjects with OSCC at early (n = 33) and advanced (n = 33) disease, OL with homogeneous (n = 33) and proliferative verrucous (n = 33) clinical presentations, and healthy controls (n = 25). Salivary IL-1α, IL-6, IL-8, IP-10, MCP-1, TNF-α, HCC-1, and PF-4 levels were analyzed by a sensitive bead-based multiplex immunoassay. Mean levels of IL-6, IL-8, TNF-α, HCC-1, MCP-1, and PF-4 differed significantly between OSCC, OL, and control saliva (p &lt

yearjournalcountryeditionlanguage
2021-04-01Journal of Clinical Medicine
10.3390/jcm10081658http://dx.doi.org/10.3390/jcm10081658