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RESEARCH PRODUCT

Chromosomal abnormalities in Waldenström's macroglobulinemia

G. GranataR. MarcenòA.m. CavallaroFabio CaradonnaP. CarboneGiusi Barbata

subject

AdultMaleCancer Researchmedicine.medical_specialtyMonosomyClone (cell biology)Chromosome rearrangements Waldenström's macroglobulinemiaBiologyGeneticsmedicineHumanseducationMolecular BiologyHomogeneously Staining RegionAgedGeneticsAged 80 and overChromosome Aberrationseducation.field_of_studyCytogeneticsMacroglobulinemiaWaldenstrom macroglobulinemiaChromosomeKaryotypeMiddle Agedmedicine.diseaseMolecular biologySettore BIO/18 - GeneticaChromosomes Human Pair 2FemaleWaldenstrom Macroglobulinemia

description

We report the results of cytogenetic studies of direct bone marrow (BM) preparations and of short-term BM and peripheral blood (PB) cultures from 17 patients with Waldenström's macroglobulinemia. We noted clonal chromosome changes in 10 patients. Abnormalities affected chromosomes X, Y, 2, 4, 5, 15, 16, 18, 19, 20, 21, and 22; in particular, chromosomes 2, 4, and 5 were involved in structural changes: a homogeneously staining region [hsr(2)], a der(4)t(4;?)(q32;?), and a 5q+. The other chromosomes were involved in numerical abnormalities, such as pseudodiploidy (a 46,X,-X,+15 clone), loss of chromosome Y, and monosomy of chromosomes 16, 18, 19, 20, 21, and 22. Nonclonal chromosome rearrangements were also observed. The results are discussed in comparison with the few data reported in the literature, and the finding of an hsr in the long arm of chromosome 2 is emphasized; indeed, this is the first report of hsr in WM. © 1992.

yearjournalcountryeditionlanguage
1992-07-15
10.1016/0165-4608(92)90078-mhttps://hdl.handle.net/10447/599677