6533b7d0fe1ef96bd125a606
RESEARCH PRODUCT
Role of Vitamin A in Mammary Gland Development and Lactation
M. Teresa CabezueloJuan R. ViñaTeresa BarberRosa Zaragozásubject
0301 basic medicineVitaminmedicine.medical_specialtymedicine.drug_classMammary glandRetinoic acidlcsh:TX341-641ReviewBreast milkBiologyvitamin A03 medical and health scienceschemistry.chemical_compoundMammary Glands AnimalPregnancyLactationInternal medicinemedicineretinoic acidinvolutionAnimalsHumansLactationRetinoidMammary Glands Human030109 nutrition & dieteticsNutrition and DieteticsMilk HumanVitamin A DeficiencyweaningRetinolNutritional Requirementsmedicine.diseaseCarotenoidsDietVitamin A deficiency030104 developmental biologymedicine.anatomical_structureEndocrinologychemistryFemalelcsh:Nutrition. Foods and food supplylactating mammary glandFood Sciencedescription
Vitamin A (all-trans-retinol), its active derivatives retinal and retinoic acid, and their synthetic analogues constitute the group of retinoids. It is obtained from diet either as preformed vitamin A or as carotenoids. Retinal plays a biological role in vision, but most of the effects of vitamin A are exerted by retinoic acid, which binds to nuclear receptors and regulates gene transcription. Vitamin A deficiency is an important nutritional problem, particularly in the developing world. Retinol and carotenoids from diet during pregnancy and lactation influence their concentration in breast milk, which is important in the long term, not only for the offspring, but also for maternal health. In this study, we review the role of vitamin A in mammary gland metabolism, where retinoid signaling is required not only for morphogenesis and development of the gland and for adequate milk production, but also during the weaning process, when epithelial cell death is coupled with tissue remodeling.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-12-01 | Nutrients |