6533b7d0fe1ef96bd125ac7b
RESEARCH PRODUCT
Amine functionalized ZrO2 nanoparticles as biocompatible and luminescent probes for ligand specific cellular imaging
Susanne StrandWolfgang TremelRuben RaggFilipe NatalioPhillip DanielDennis StrandJugal Kishore SahooMuhammad Nawaz TahirKaloian Koynovsubject
Zro2 nanoparticlesMaterials scienceLigandBiomedical EngineeringNanotechnologyGeneral ChemistryGeneral MedicineBiocompatible materialchemistry.chemical_compoundchemistrySurface modificationGeneral Materials ScienceAmine gas treatingLuminescencePhosphineCarbodiimidedescription
Surface functionalized ZrO2 nanoparticles show strong photoluminescence and are a versatile tool for cellular targeting due to their chemical functionality. They are highly photostable, biocompatible and amenable to coupling with bioligands (e.g. secondary goat anti-rabbit antibody (GAR) and tri-phenyl phosphine (TPP)) via carbodiimide chemistry. Antibody (GAR) functionalized ZrO2 nanoparticles were used to image the nuclear protein Sirt6, whereas triphenyl phosphonium ion (TPP) functionalized ZrO2 nanoparticles specifically targeted the mitochondria. The versatility and easiness of the ZrO2 surface modification opens up new possibilities for designing non-toxic water dispersible and photostable photoluminescent NPs.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-01 | Journal of Materials Chemistry B |