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RESEARCH PRODUCT
Factors Associated With Severe Gastrointestinal Diagnoses in Children With SARS-CoV-2 Infection or Multisystem Inflammatory Syndrome
Andrea Lo VecchioSilvia GarazzinoAndrea SmarrazzoElisabetta VenturiniMarco PoetaPaola BerleseMarco DeninaAntonella MeiniSamantha BosisLuisa GalliSalvatore CazzatoGiangiacomo NicoliniGianluca VergineRoberta GiaccheroGiuseppina BallardiniIcilio DodiFilippo Maria SalviniPaolo ManzoniGiuliana FerranteVera QuadriAndrea CampanaRaffaele BadolatoAlberto VillaniAlfredo GuarinoGuido Castelli GattinaraGianluca Tornesesubject
MaleGastrointestinalPrognosiGastrointestinal DiseasesGastrointestinal DiseaseMultisystem Inflammatory SyndromeCOVID-19; Child; Child Preschool; Female; Gastrointestinal Diseases; Humans; Male; Prognosis; Radiography; Retrospective Studies; SARS-CoV-2; Systemic Inflammatory Response Syndromemacromolecular substancesSarsCoV2PediatricsRetrospective StudieHumansChildPreschoolChildrenOriginal InvestigationRetrospective StudiesSARS-CoV-2ResearchGastrointestinal Children SARS-CoV-2 Multisystem Inflammatory SyndromeCOVID-19General MedicinePrognosisSettore MED/38gastrointestinalSystemic Inflammatory Response SyndromeRadiographyOnline OnlyChild PreschoolFemaleSarsCoV2; COVID-19; gastrointestinalHumandescription
Key Points Question Is COVID-19 associated with severe gastrointestinal manifestations in children? Findings In this multicenter cohort study of 685 Italian children with COVID-19, 10% showed severe gastrointestinal involvement characterized by diffuse adeno-mesenteritis, appendicitis, abdominal fluid collection, ileal intussusception, or pancreatitis. Children older than 5 years and those presenting with abdominal pain, leukopenia, or receiving a diagnosis of multisystem inflammatory syndrome were more likely to have severe gastrointestinal manifestations. Meaning Severe gastrointestinal involvement is not uncommon in children with COVID-19, and awareness about its frequency and presentation may help practitioners to appropriately manage children at risk of severe outcomes.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-12-20 |