6533b7d0fe1ef96bd125b676
RESEARCH PRODUCT
false
subject
0301 basic medicineSenescenceCancer ResearchMechanism (biology)CancerCellular senescenceBiologymedicine.disease_causemedicine.diseasePhenotypeNitric oxideCancer treatment03 medical and health scienceschemistry.chemical_compound030104 developmental biology0302 clinical medicineOncologychemistry030220 oncology & carcinogenesismedicineCancer researchCarcinogenesisdescription
Cellular senescence is a cell state involved in both physiological and pathological processes such as age-related diseases and cancer. While the mechanism of senescence is now well known, its role in tumorigenesis still remains very controversial. The positive and negative effects of senescence on tumorigenesis depend largely on the diversity of the senescent phenotypes and, more precisely, on the senescence-associated secretory phenotype (SASP). In this review, we discuss the modulatory effect of nitric oxide (NO) in SASP and the possible benefits of the use of NO donors or iNOS inducers in combination with senotherapy in cancer treatment.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-05-02 | Cancers |