Dehydroepiandrosterone Induction of the Abcd2 and Abcd3 Genes encoding peroxisomal ABC Transporters

6533b7d0fe1ef96bd125b69f

RESEARCH PRODUCT

Dehydroepiandrosterone Induction of the Abcd2 and Abcd3 Genes encoding peroxisomal ABC Transporters

Maurice Bugaut Catherine Gondcaille Stéphane Savary Stéphane Fourcade Fabien Gueugnon Martine El Etr Françoise Cadepond Fabrice Lambert Jérôme Bellenger

subject

chemistry.chemical_classification Sulfation Enzyme Biochemistry biology chemistry ABCD3 ABCD2 biology.protein Dehydroepiandrosterone ATP-binding cassette transporter Peroxisome Gene

description

Dehydroepiandrosterone (DHEA) is a peroxisome proliferator known to increase the expression of the genes encoding the peroxisomal s-oxidation enzymes in rodents. Using RT-PCR, we analysed the expression of the Abcd2 and Abcd3 genes encoding the peroxisomal ABC transporters ALDRP (ALD related protein) and PMP70 (70 kDa peroxisomal membrane protein) in primary cultures of rats hepatocytes treated with sulfated DHEA. We observed a time (12-72h) and dose (125-500μM) dependent increase in the expression of both genes.

year	journal	country	edition	language
2003-01-01

https://doi.org/10.1007/978-1-4419-9072-3_31

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