6533b7d0fe1ef96bd125ba8d
RESEARCH PRODUCT
Stick around: Cell-Cell Adhesion Molecules during Neocortical Development
Cristina Gil-sanzJaime Fabra-beserDavid De Agustín-duránIsabel Mateos-whitesubject
Extracellular matrixCorticogenesisNeocortexmedicine.anatomical_structureChemistryCadherinNectinCell adhesion moleculeCell surface receptorSynaptogenesismedicineanatomy_morphologyNeurosciencedescription
The neocortex is an exquisitely organized structure achieved through complex cellular processes from the generation of neural cells to their integration into cortical circuits after complex migration processes. During this long journey, neural cells need to stablish and release adhesive interactions through cell surface receptors known as cell adhesion molecules (CAMs). Several types of CAMs have been described regulating different aspects of neurodevelopment. Whereas some of them mediate interactions with the extracellular matrix, others allow contacts with additional cells. In this review, we will focus on the role of two important families of cell-cell adhesion molecules (C-CAMs), classical cadherins and nectins, as well as in their effectors, in the control of fundamental processes related with corticogenesis, with especial attention in the cooperative actions among the two families of C-CAMs.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-12-10 |