Terbium Medical Radioisotope Production: Laser Resonance Ionization Scheme Development

6533b7d1fe1ef96bd125baf1

RESEARCH PRODUCT

Terbium Medical Radioisotope Production: Laser Resonance Ionization Scheme Development

Vadim Maratovich Gadelshin Vadim Maratovich Gadelshin Roberto Formento Cavaier Roberto Formento Cavaier Ferid Haddad Reinhard Heinke Reinhard Heinke Reinhard Heinke Thierry Stora Dominik Studer Felix Weber Klaus Wendt

subject

Medicine (General)theranostics Materials science CERN-MEDICIS Ion beam 530 Physics Gadolinium 610 Medizin chemistry.chemical_element Terbium TERBIUM SURFACE PROPERTY Isotope separation law.invention GADOLINIUM R5-920 COMPARATIVE STUDY law Ionization 610 Medical sciences LASER RESONANCE IONIZATION SAPPHIRE LASER [TI]ARTICLE RADIOCHEMISTRY isotope separation TANTALUM Original Research THERANOSTICS Ti:Sapphire laser RISIKO MASS SEPARATOR terbium ATOMIC SPECTROMETRY Radiochemistry Ti:sapphire laser General Medicine 530 Physik Characterization (materials science)CONTROLLED STUDY chemistry RISIKO mass separator ION CURRENT Medicine ISOTOPE SEPARATION IONIZATION Atomic ratio laser resonance ionization gadolinium

description

Terbium (Tb) is a promising element for the theranostic approach in nuclear medicine. The new CERN-MEDICIS facility aims for production of its medical radioisotopes to support related R&D projects in biomedicine. The use of laser resonance ionization is essential to provide radioisotopic yields of highest quantity and quality, specifically regarding purity. This paper presents the results of preparation and characterization of a suitable two-step laser resonance ionization process for Tb. By resonance excitation via an auto-ionizing level, the high ionization efficiency of 53% was achieved. To simulate realistic production conditions for Tb radioisotopes, the influence of a surplus of Gd atoms, which is a typical target material for Tb generation, was considered, showing the necessity of radiochemical purification procedures before mass separation. Nevertheless, a 10-fold enhancement of the Tb ion beam using laser resonance ionization was observed even with Gd:Tb atomic ratio of 100:1. © Copyright © 2021 Gadelshin, Formento Cavaier, Haddad, Heinke, Stora, Studer, Weber and Wendt. This research project has been supported by a Marie Skłodowska-Curie Innovative Training Network Fellowship of the European Commission’s Horizon 2020 Programme under contract number 642889 MEDICIS-PROMED; by the German Federal Ministry of Education and Research under the consecutive projects 05P12UMCIA and 05P15UMCIA. It has been also partially supported by Equipex ARRONAX-Plus (ANR-11-EQPX-0004), Labex IRON (ANR-11-LABX-18-01), ISITE NExT (ANR-16-IDEX-0007).

year	journal	country	edition	language
2021-10-01

https://hdl.handle.net/10995/111829