Metal-free electrochemical fluorodecarboxylation of aryloxyacetic acids to fluoromethyl aryl ethers

6533b7d1fe1ef96bd125c26a

RESEARCH PRODUCT

Metal-free electrochemical fluorodecarboxylation of aryloxyacetic acids to fluoromethyl aryl ethers

John D. Herszman Yuji Kurimoto Yuji Kurimoto Sven Ruf Siegfried R. Waldvogel Goswinus H. M. De Kruijff Aaron Schüll Michael Berger

subject

Chemistry chemistry.chemical_compound chemistry Metal free Supporting electrolyte Decarboxylation Aryl General Chemistry Electrochemistry Electrosynthesis Combinatorial chemistry Fluoride

description

Electrochemical decarboxylation of aryloxyacetic acids followed by fluorination provides easy access to fluoromethyl aryl ethers. This electrochemical fluorodecarboxylation offers a sustainable approach with electric current as traceless oxidant. Using Et3N·5HF as fluoride source and as supporting electrolyte, this simple electrosynthesis affords various fluoromethoxyarenes in yields up to 85%.

year	journal	country	edition	language
2020-06-01	Chemical Science

https://doi.org/10.1039/d0sc02417a

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