6533b7d1fe1ef96bd125c3ca

RESEARCH PRODUCT

Parvovirus capsid disorders cholesterol-rich membranes.

Anna R. MäkeläSanna KirjavainenKirsi I. PakkanenMatti VuentoChristian Oker-blomNina RintanenTuula O. Jalonen

subject

12-DipalmitoylphosphatidylcholineParvovirus CanineEndosomeMembrane Fluidityanimal diseasesvirusesEndocytic cycleBiophysicsBiochemistryViruschemistry.chemical_compoundCapsidMolecular BiologybiologyCholesterolParvovirusCanine parvovirusMembranes ArtificialCell BiologyHydrogen-Ion Concentrationbiology.organism_classificationVirologyCell biologyMembraneCholesterolCapsidchemistryCapsid Proteins

description

In this study canine parvovirus, CPV, was found to induce disorder in DPPC:cholesterol membranes in acidic conditions. This acidicity-induced fluidizing effect is suggested to originate from the N-terminus of the viral capsid protein VP1. In accordance with the model membrane studies, a fluidizing effect was seen also in the endosomal membranes during CPV infection implying an important functional role of the fluidization in the endocytic entry of the virus.

yearjournalcountryeditionlanguage
2008-12-10Biochemical and biophysical research communications
10.1016/j.bbrc.2008.12.116https://pubmed.ncbi.nlm.nih.gov/19118523