6533b7d1fe1ef96bd125d630

RESEARCH PRODUCT

Cylindrical Brush Polymers with Polysarcosine Side Chains: A Novel Biocompatible Carrier for Biomedical Applications

Manfred SchmidtKarl FischerChristian HörtzEva WächtersbachMatthias BarzSandra DeckerLeonard KapsAlexander BirkeDetlef Schuppan

subject

chemistry.chemical_classificationSarcosineBioconjugationPolymers and PlasticsBiocompatibilityOrganic ChemistryCationic polymerizationPolymerInorganic Chemistrychemistry.chemical_compoundPolymerizationchemistryPolymer chemistryMaterials ChemistrySide chainProtein adsorption

description

Cylindrical brush polymers constitute promising polymeric drug delivery systems (nanoDDS). Because of the densely grafted side chains such structures may intrinsically exhibit little protein adsorption (“stealth” effect) while providing a large number of functional groups accessible for bioconjugation reactions. Polysarcosine (PSar) is a highly water-soluble, nonionic and nonimmunogenic polypeptoid based on the endogenous amino acid sarcosine (N-methyl glycine). Here we report on the synthesis, characterization and biocompatibility of cylindrical brush polymers with either polysarcosine side chains or poly-l-lysine-b-polysarcosine side chains. The latter leads to block copolypept(o)id based core–shell cylindrical brushes with a cationic poly-l-lysine (PLL) core and a neutral polysarcosine corona. The cylindrical brush polymers were prepared by ring-opening polymerization of the respective N-carboxyanhydrides (NCA) from a macroinitiator chain. Preliminary experiments on complex formation with siRNA demonst...

yearjournalcountryeditionlanguage
2015-03-26Macromolecules
https://doi.org/10.1021/ma502497x