6533b7d1fe1ef96bd125d638
RESEARCH PRODUCT
Synthesis and pharmacological activity of silyl isoxazolines 2
S. GermaneE. LukevicsVija KlusaA. KemmeJ. SkuyinsJuris PopelisSimons SvirskisV. Dirnenssubject
chemistry.chemical_compoundMolecular geometryNitrilechemistrySilylationStereochemistryOxideGeneral Materials ScienceBiological activityGeneral ChemistryMedicinal chemistryCycloadditiondescription
Silyl isoxazolines have been synthesized by [2+3] cycloaddition reaction of nitrile oxides to vinyl- and allylsilanes. The addition of 3-pyridylnitrile oxide to 1,3-divinyl-1,1,3,3-tetraphenyldisiloxane affords 1,3-bis{5-[3-(3-pyridyl)isoxazolin-2-yl]}-1,1,3,3-tetraphenyldisiloxane; the latter exists as a mixture of trans- and cis-isomers.The bond angle of the Si–O–Si fragment in thetrans-isomer equals 180(3)° and in the cis-isomer it is 162(3)°.The pharmacological properties of 4-[3-(5-trimethylsilylisoxazolin-2-yl)]pyridinium-chloride have been studied.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-01-01 | Silicon Chemistry |