6533b7d1fe1ef96bd125d697

RESEARCH PRODUCT

A New Major Triterpene Saponin from the Roots of Cucurbita foetidissima

Bernard HanquetMaria CorreiaGhezala GaidiAbderrazak MaroufRudolf BauerBruno ChauffertMa Lacaille-dubois

subject

StereochemistryMolecular Sequence DataSaponinPharmaceutical ScienceUronic acidPharmacognosyPlant RootsAnalytical Chemistrychemistry.chemical_compoundTriterpeneDrug DiscoveryCarbohydrate ConformationTumor Cells CulturedHumansOleanolic AcidCytotoxicityPharmacologychemistry.chemical_classificationbiologySpectrum AnalysisOrganic ChemistryGlycosideSaponinsbiology.organism_classificationCucurbitaceaeCarbohydrate SequenceComplementary and alternative medicineHeteronuclear moleculechemistryBiochemistryMolecular MedicineCucurbita foetidissimaDrug Screening Assays Antitumor

description

Foetidissimoside B (1), a novel triterpene saponin, was isolated from the roots of Cucurbita foetidissima. Based on spectroscopic data, especially direct and long-range heteronuclear 2D NMR analysis and on chemical transformations, the structure of 1 was elucidated as 3-O-beta-D-glucuronopyranosyl-echinocystic acid 28-O-beta-D-glucopyranosyl-(1-->3)-beta-D-xylopyranosyl(1-->3)-[beta- D-xylopyranosyl (1-->4)]-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside . Compound 1 did not show any ability to potentiate in vitro cisplatin cytotoxicity in a human colon cancer cell line.

yearjournalcountryeditionlanguage
2000-01-29Journal of Natural Products
https://doi.org/10.1021/np9902800