6533b7d1fe1ef96bd125d7d9

RESEARCH PRODUCT

Prevalence of human papilloma virus infection in patients with male accessory gland infection

Guido ScaliaEnzo VicariS. La VigneraRosaria SchillaciAldo E. CalogeroRosita A. CondorelliAntonino PerinoGiuseppe MorgiaC. Franchina

subject

AdultMaleHPVSemenComorbidityMAGIBiologyGroup AGroup BSemenmedicinePrevalenceHumansPapillomaviridaeInfertility MaleInflammationPapillomavirus InfectionsHPV infectionvirus diseasesObstetrics and GynecologyHPV MAGI Prevalencemedicine.diseaseSettore MED/40 - Ginecologia E OstetriciaSpermfemale genital diseases and pregnancy complicationsProstatitisSemen AnalysisHPV; MAGI; PrevalenceReproductive MedicineMale accessory gland infectionImmunologySperm MotilityGenital Diseases Malemedicine.symptomNested polymerase chain reactionMagiDevelopmental Biology

description

The frequency of human papillomavirus (HPV) infection in the semen of patients with male accessory gland infection (MAGI) was evaluated. One hundred infertile patients with MAGI were classified into group A: patients with an inflammatory MAGI (n = 48) and group B: patients with a microbial form (n = 52). Healthy age-matched fertile men (34.0 ± 4.0 years) made up the control group (n = 20). Amplification of HPV DNA was carried out by HPV-HS Bio nested polymerase chain reaction for the detection of HPV DNA sequences within the L1 ORF. Ten patients in group A (20.8%) and 15 patients in group B (28.8%) had a HPV infection; two controls (10.0%) had HPV infection. Patients with MAGI had a significantly higher frequency of HPV infection compared with controls; patients with a microbial MAGI had significantly higher frequency of HPV infection compared with patients with an inflammatory form (both P < 0.05). Patients with MAGI and HPV had a slight, but significantly lower sperm progressive motility and normal morphology compared with patients with MAGI HPV-negative (P < 0.05). Elevated frequency of HPV infection occurred in patients with MAGI, suggesting that HPV should be investigated in the diagnostic work-up of these patients.

yearjournalcountryeditionlanguage
2015-04-01
10.1016/j.rbmo.2014.12.016http://hdl.handle.net/20.500.11769/31629