6533b7d1fe1ef96bd125d93f
RESEARCH PRODUCT
Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes
Henrik HjalgrimJoseph VijaiBengt GlimeliusKimberly A. BertrandImmaculata De VivoEve RomanMartha GlennNathaniel RothmanYolanda BenaventeZhaoming WangJu-hyun ParkAnneclaire J. De RoosAnneclaire J. De RoosJohn J. SpinelliDemetrius AlbanesPaul BrennanEmanuele AngelucciMariagrazia ZuccaQing LanKari E. NorthPaige M. BracciMark P. PurdueMarco RaisMelissa C. SoutheyAlain MonnereauAlain MonnereauAhmet DoganGraham G. GilesGraham G. GilesRobert J. KleinPeter KraftLesley F. TinkerLaurie BurdettLucia CondeLucia CondeCarrie A. ThompsonJames MckayMartyn T. SmithGöran RoosYan W. AsmannDennis D. WeisenburgerElizabeth A. HollyThomas E. WitzigLiming LiangPaul I.w. De BakkerAlex SmithJarmo VirtamoCharles E. LawrencePatricia HartgeKaren CurtinAnthony StainesNikolaus BeckerNicola J. CampCharles C. ChungDegui ZhiBrenda M. BirmannW. Ryan DiverRoel VermeulenSonja I. BerndtTongzhang ZhengSilvia De SanjoséEleanor KaneJames R. CerhanChristopher R. FlowersJoseph F. FraumeniStephen J. ChanockStephen M. AnsellAngela Brooks-wilsonAngela Brooks-wilsonKenneth OffitJinyan HuangMads MelbyeMads MelbyeEdward GiovannucciBaoshan MaBaoshan MaTracy LightfootBrian K. LinkRichard K. SeversonTheodore R. HolfordYawei ZhangAnne TjønnelandMeredith YeagerWendy CozenAnne J. NovakLauren R. TerasClaire M. VajdicLisa A. Cannon-albrightLenka ForetovaChristine F. SkibolaChristine F. SkibolaSophia S. WangHans-olov AdamiHans-olov AdamiAndrew D. ZelenetzJenny TurnerPaolo VineisCorinne HaiounHervé TillyAnne Zeleniuch-jacquotteThomas M. HabermannPaolo BoffettaJacqueline ClavelJacqueline ClavelHerve GhesquieresStephanie J. WeinsteinLindsay M. MortonSusan L. SlagerSimon CrouchGilles SallesGilles SallesRachel S. KellyRachel S. KellyKarin E. SmedbyAmy HutchinsonDavid G. CoxElio RiboliJacques RibyJacques RibyRebecca D. JacksonMark LiebowThierry Jo MolinaDanylo J. VillanoMarc MaynadieYuanqing YeHeiner BoeingJian GuBrian C.-h. ChiuSimonetta Di LolloMitchell J. MachielaAlexandra NietersXifeng WuRudolph Kaakssubject
0301 basic medicineSerumMaleLymphomaanalysisChronic lymphocytic leukemiaFollicular lymphomaGlobal Health[ SDV.CAN ] Life Sciences [q-bio]/Cancerimmunologysurgery0302 clinical medicineEndocrinologyimmune system diseasessingle nucleotide polymorphismGermanyhemic and lymphatic diseasesLondon80 and overOdds RatiogeneticsProspective StudiesB-cell lymphomaAssociation Studies ArticleGenetics (clinical)Aged 80 and overeducation.field_of_studytelomereGenomeLeukemiaAge FactorsGeneral MedicineEnvironmental exposureGenomicsMiddle Agedb-cell lymphomasmall cell lymphomaItaly030220 oncology & carcinogenesisMedicineepidemiologyFemaleFranceRisk of B-cell lymphoma subtypesRiskAdultCanadaChinaLymphoma B-CellGenotypeAdolescentleukocytesetiologyPopulationPopulation[SDV.CAN]Life Sciences [q-bio]/CancerBiologyEnvironmentRisk AssessmentmethodsTime03 medical and health sciencesmedicineHumansFamilyGenetic Predisposition to DiseaseeducationMolecular BiologyAllelesOccupational HealthGenetic Association StudiesAgedB-CellInternational AgenciesOdds ratioEnvironmental Exposuremedicine.diseaseTelomereNon-Hodgkin's lymphoma030104 developmental biologyImmunologyphysiologyChronic DiseasepathologyLaboratoriesmetabolismdescription
International audience; Evidence from a small number of studies suggests that longer telomere length measured in peripheral leukocytes is associated with an increased risk of non-Hodgkin lymphoma (NHL). However, these studies may be biased by reverse causation, confounded by unmeasured environmental exposures and might miss time points for which prospective telomere measurement would best reveal a relationship between telomere length and NHL risk. We performed an analysis of genetically inferred telomere length and NHL risk in a study of 10 102 NHL cases of the four most common B-cell histologic types and 9562 controls using a genetic risk score (GRS) comprising nine telomere length-associated single-nucleotide polymorphisms. This approach uses existing genotype data and estimates telomere length by weighing the number of telomere length-associated variant alleles an individual carries with the published change in kb of telomere length. The analysis of the telomere length GRS resulted in an association between longer telomere length and increased NHL risk [four B-cell histologic types combined; odds ratio (OR) = 1.49, 95% CI 1.22-1.82,P-value = 8.5 x 10(-5)]. Subtype-specific analyses indicated that chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) was the principal NHL subtype contributing to this association (OR = 2.60, 95% CI 1.93-3.51,P-value = 4.0 x 10(-10)). Significant interactions were observed across strata of sex for CLL/SLL and marginal zone lymphoma subtypes as well as age for the follicular lymphoma subtype. Our results indicate that a genetic background that favors longer telomere length may increase NHL risk, particularly risk of CLL/SLL, and are consistent with earlier studies relating longer telomere length with increased NHL risk
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-04-01 |